These stress granule thingies have been following me like a bad smell these last few months. First they popped up as a side remark in one podcast, then in another. And now again in Philip Ball's book How Life Works: A User's Guide to the New Biology*. So third time round I thought I'd better...
https://www.the-scientist.com/news-opinion/hibernating-bears-provide-clue-to-preventing-serious-clots-in-humans-71064
research paper (not full text)
Sleep like a bear
Reduced expression of a platelet protein protects against thrombosis during chronic immobilization...
HSF2 is required to maintain cell-cell adhesion
HSF2 deficiency leads to downregulation of cadherin superfamily genes
Impaired cell-cell adhesion sensitizes cells to prolonged proteotoxic stress
Cadherin-mediated cell-cell adhesion is a survival determinant upon proteotoxicity...
Abstract
Although the accessory proteins are considered non-essential for coronavirus replication, accumulating evidences demonstrate they are critical to virus-host interaction and pathogenesis. Orf9b is a unique accessory protein of SARS-CoV-2 and SARS-CoV. It is implicated in immune evasion...
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