glymphatic system

Asymmetrical glymphatic dysfunction in patients with long Covid associated neurocognitive impairment- correlation with BBB disruption Chaganti, Joga R.; Talekar, Tanush K.; Brew, Bruce James BACKGROUND AND PURPOSE The glymphatic system, a waste clearance pathway, has been implicated in several...

Highlights • Norepinephrine release from the locus coeruleus drives slow vasomotion in NREM sleep • Infraslow norepinephrine oscillations control opposing changes in blood and CSF volumes • Norepinephrine oscillation frequency during NREM sleep predicts glymphatic clearance • The sleep aid...

The perivascular space is a conduit for cerebrospinal fluid flow in humans: A proof-of-principle report Yamamoto, Erin A.; Bagley, Jacob H.; Geltzeiler, Mathew; Sanusi, Olabisi R.; Dogan, Aclan; Liu, Jesse J.; Piantino, Juan The glymphatic pathway was defined in rodents as a network of...

Impaired glymphatic function as a biomarker for subjective cognitive decline: An exploratory dual cohort study Yuxia Li, Luyao Wang, Jiayi Zhong, Huanyu Xu, Ying Han, Chuantao Zuo, Jiehui Jiang Background: Subjective cognitive decline (SCD) has been recognized as a potential risk stage for...

Assessing Cerebral Microvascular Volumetric Pulsatility with High-Resolution 4D CBV MRI at 7T Fanhua Guo; Chenyang Zhao; Qinyang Shou; Ning Jin; Kay Jann; Xingfeng Shao; Danny JJ Wang Arterial pulsation is crucial for promoting fluid circulation and for influencing neuronal activity. Previous...

COVID-19 and chronic fatigue syndrome: Is the worst yet to come? Peter Wostyn https://www.sciencedirect.com/science/article/pii/S0306987720333600?dgcid=rss_sd_all From the same author...

Waste Clearance in the Brain Kaur, Jasleen; Fahmy, Lara M.; Davoodi-Bojd, Esmaeil; Zhang, Li; Ding, Guangliang; Hu, Jiani; Zhang, Zhenggang; Chopp, Michael; Jiang, Quan Waste clearance (WC) is an essential process for brain homeostasis, which is required for the proper and healthy functioning...

Abstract The accumulation of metabolic waste is a leading cause of numerous neurological disorders, yet we still have only limited knowledge of how the brain performs self-cleansing. Here we demonstrate that neural networks synchronize individual action potentials to create large-amplitude...

Glymphatic system dysfunction in recovered patients with mild COVID-19: A DTI-ALPS study Lin Wu; Zhi Zhang; Xiao Liang; Yao Wang; Yuan Cao; Meng Li; Fuqing Zhou Central nervous sequelae are often reported in recovered patients with COVID-19. It is not clear whether recovered COVID-19 patients...

The Glymphatic System: A Beginner’s Guide Jessen, Nadia Aalling; Munk, Anne Sofie Finmann; Lundgaard, Iben; Nedergaard, Maiken The glymphatic system is a recently discovered macroscopic waste clearance system that utilizes a unique system of perivascular tunnels, formed by astroglial cells, to...

Brain borders at the central stage of neuroimmunology Rustenhoven, Justin; Kipnis, Jonathan The concept of immune privilege suggests that the central nervous system is isolated from the immune system. However, recent studies have highlighted the borders of the central nervous system as central...

Now published - link here ********* Preprint Association of Baseline Cerebrovascular Reactivity and Development of Enlarged Perivascular Spaces in the Basal Ganglia Timothy J Libecap; Christopher E Bauer; Valentinos Zachariou; Colleen A Pappas; Flavius D Raslau; Peiying Liu; Hanzhang Lu; Brian...

Research on rodents. https://www.the-scientist.com/news-opinion/variants-in-water-channel-gene-tied-to-more-restful-sleep-67529 Paper here

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