Thought we should have a thread for this trial as it is often cited as evidence of efficacy of LDN in fibromyalgia.
Randomized Controlled Trial
Arthritis Rheum. 2013 Feb;65(2):529-38. doi: 10.1002/art.37734.
Low-dose naltrexone for the treatment of fibromyalgia: findings of a small...
*This post is in the process of being updated. People have given me feedback that sharing the Bluesky/Twitter threads is not a preferred/accessible option, so I will be taking the time to try to convey the relevant information here (it will likely have to be spread across multiple threads...
Multifaceted evolution focused on maximal exploitation of domain knowledge for the consensus inference of Gene Regulatory Networks
Adrián Segura-Ortiz, Karen Giménez-Orenga, José García-Nieto, Elisa Oltra, José F. Aldana-Montes
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Highlights
• BIO-INSIGHT optimizes GRN...
Recognizing the role of fibromyalgia in post-exertional malaise
Alessandro Giollo; Mariangela Salvato; Andrea Doria
The recent opinion by Charlton et al. published in Trends in Endocrinology & Metabolism [1] provides a thought-provoking discussion of the overlap between long coronavirus disease...
Genome-wide association study identifies novel genetic variants associated with widespread pain in the UK Biobank, 2025, Pan
Abstract
Objectives:
Widespread pain is a hallmark characteristic of fibromyalgia, commonly affecting older individuals. This study aimed to identify novel genetic...
This is disapointing…
…"This implies that experience of trauma and distress might elicit a specific immune-biological response in genetically or otherwise (eg, past infection, toxicity, trauma) vulnerable individuals, which includes the production of harmful noninflammatory autoantibodies." …...
ABSTRACT
Background
Functional medical disorders (FMDs) refer to persistent physical symptoms that cause impairment or disability, but which cannot be explained by routine medical testing. Negative perceptions towards FMDs exist amongst a variety of healthcare professionals, including medical...
https://www.sciencedirect.com/science/article/abs/pii/S1542012425000850
The Ocular Surface
Volume 38, October 2025, Pages 64-71
Heightened visual light sensitivity discomfort measured by the ocular photosensitivity analyzer is associated with chronic ocular pain
Ema V. Karakoleva a b c...
Abstract
Fibromyalgia syndrome (FMS) is a chronic pain disorder characterised by widespread musculoskeletal pain, fatigue, and cognitive dysfunction, with no definitive biomarkers or mechanism-based treatments. Emerging evidence suggests that immune dysregulation may contribute to the FMS...
Interesting article on how ‘Central Sensitivity Syndromes’ evolved by Rheumatologists Milton Cohen and John Quintner from 2018. Seems this theory has fallen away somewhat in the last few years.
‘In 2007, Dr Mohammed Yunus from Illinois noted that a number of diverse, medically controversial...
The pivotal role of central sensitization in long COVID, fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome
Don L. Goldenberg
Introduction
Long COVID is a condition characterized by persistent unexplained symptoms following COVID-19 infection. These symptoms are not related to...
Postacute COVID-19 syndrome and fibromyalgia syndrome are associated with anti-satellite glial cell IgG serum autoantibodies but only fibromyalgia syndrome serum-IgG is pronociceptive
Berwick, Richard J.; Sahbaie, Peyman; Kenny, Grace; Guo, Tian-Zhi; Neiland, Harvey; Andersson, David A.; Clark...
Low-Dose Naltrexone for Severe Fibromyalgia Syndrome: A Report of a Case With Two-Year Follow-Up
Ulrich Moser
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Abstract
Fibromyalgia syndrome (FMS) is characterized by diffuse musculoskeletal pain associated with daytime fatigue, sleep disturbance, cognitive deficits, and...
323 - Toxic Exposures and Chronic Overlapping Pain Conditions in a Veteran Cohort: Gender-Specific Insights from the Million Veteran Program
Armand Gerstenberger, Niloofar Afari, Marianna Gasperi
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Chronic overlapping pain conditions (COPCs) include migraine, tension...
Ignored, Dismissed, and Minimized: Understanding the Harmful Consequences of Invalidation in Health Care—A Systematic Meta-Synthesis of Qualitative Research
Allyson C. Bontempo, John M. Bontempo, Paul R. Duberstein
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Abstract
The upsurge in the prevalence of contested...
Highlights
• Transplanting gut microbiota from women with fibromyalgia into mice induces pain
• It also induces immune activation, metabolomic changes, and reduced skin innervation
• Gut microbiota promotes pain through several mechanisms
Summary
Fibromyalgia is a prevalent syndrome...
Discovery of Target Genes for Fibromyalgia through Bioinformatics Analysis
Mao Guo, Botao Zhang
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Abstract
Fibromyalgia (FM) is a chronic condition marked by widespread pain, fatigue, and other debilitating symptoms, affecting 2−4% of the population, predominantly women...
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