fatty acid metabolism

Abstract: Background. Long COVID involves persistent symptoms after COVID-19 recovery, affecting multiple organ systems for months or years. Risk factors include female sex, prior chronic conditions, severe SARS-CoV-2 infection, reinfections, and lack of vaccination. As a major public health...

Proteomic and metabolomic profiling of plasma uncovers immune responses in patients with Long COVID-19 Yulin Wei, Hongyan Gu, Jun Ma, Xiaojuan Mao, Bing Wang, Weiyan Wu, Shimin Yu, Jinyuan Wang, Huan Zhao, yanbin he [Preprint] Abstract Long COVID is an often-debilitating condition with...

Unraveling SARS-CoV-2 Host-Response Heterogeneity through Longitudinal Molecular Subtyping Hospitalized COVID-19 patients exhibit diverse immune responses during acute infection, which are associated with a wide range of clinical outcomes. However, understanding these immune heterogeneities...

Macrophage SREBP1 regulates skeletal muscle regeneration Oishi, Yumiko; Koike, Hiroyuki; Kumagami, Naoki; Nakagawa, Yoshimi; Araki, Masaya; Taketomi, Yoshitaka; Miki, Yoshimi; Matsuda, Shigeru; Matsuzaka, Takashi; Ozawa, Hitoshi; Shimano, Hitoshi; Murakami, Makoto; Manabe, Ichiro Macrophages...

Understanding COVID-19 progression with longitudinal peripheral blood mononuclear cell proteomics: Changes in the cellular proteome over time Giuseppe Gianini Figueirêdo Leite; Milena Karina Colo Brunialti; Paula M. Peçanha-Pietrobom; Paulo R. Abrão Ferreira; Jaquelina Sonoe Ota-Arakaki; Edecio...

Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response Hyun-Eui Kim; Ana Rodrigues Grant; Milos S. Simic; Rebecca A. Kohnz; Daniel K. Nomura; Jenni Durieux; Celine E. Riera; Melissa Sanchez; Erik Kapernick; Suzanne Wolff; Andrew Dillin Summary Defects in mitochondrial...

A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy Nneka Southwell; Guido Primiano; Viraj Nadkarni; Nabeel Attarwala; Emelie Beattie; Dawson Miller; Sumaitaah Alam; Irene Liparulo; Yevgeniya I Shurubor; Maria Lucia Valentino; Valerio Carelli; Serenella...

https://www.mdpi.com/1422-0067/24/3/2010 Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disabling multisystem illness in which individuals are plagued with fatigue, inflammatory symptoms, cognitive dysfunction, and the hallmark symptom, post-exertional malaise. While...

Hot off the press, just published today in Frontiers in Pharmacology. A group of researchers in China used metabolomics (measuring the concentration of many metabolism-related chemicals in the blood) to compare healthy controls with Covid-19 patients who were admitted to Jiaxing Hospital, but...

Abstract In this study we demonstrated through analytic considerations and numerical studies that the mitochondrial fatty-acid β-oxidation can exhibit bistable-hysteresis behavior. In an experimentally validated computational model we identified a specific region in the parameter space in which...

This post on Phys.org just caught my eye. I didn't realize there was a distinct mitochondrial cycle for this essential part of cell metabolism. Here's the primary citation. This is the first I have heard of MEPAN and the foundation to study it. This devastating disease could be a key to the...