depression

Peripheral leptin receptor gene network modulates the impact of childhood adversity on mental health disorders Sobreira de Lima; Barth; Arcego; de Mendonça Filho; Patel; Wang; Elgbeili; Pokhvisneva; Parent; Levitan; Kobor; Dalmaz; Silveira Psychiatric disorders are highly prevalent and often...

Disentangling nature and nurture: Exploring the genetic background of depressive symptoms in the absence of recent stress exposure using a GWAS approach Berta Erdelyi-Hamza, Dora Torok, Sandor Krause, Nora Eszlari, Gyorgy Bagdy, Gabriella Juhasz, Xenia Gonda Highlights • Heterogeneity of...

Chronic stress remodels brain homeostasis, in which persistent change leads to depressive disorders. As a key modulator of brain homeostasis, it remains elusive whether and how brain autophagy is engaged in stress dynamics. Here we discover that acute stress activates, whereas chronic stress...

Gene discovery and biological insights into anxiety disorders from a large-scale multi-ancestry genome-wide association study Eleni Friligkou, Solveig Løkhammer, Brenda Cabrera-Mendoza, Jie Shen, Jun He, Giovanni Deiana, Mihaela Diana Zanoaga, Zeynep Asgel, Abigail Pilcher, Luciana Di Lascio...

Affective disorders and chronic inflammatory conditions: Analysis of 1.5 million participants in Our Future Health Arish Mudra Rakshasa-Loots, Duncan Swiffen, Christina Steyn, Katie F. M. Marwick, Daniel J. Smith [Line breaks added] Abstract Chronic inflammation is associated with psychiatric...

Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes Abstract Individual sensitivity to environmental exposures may be genetically influenced. This genotype-by-environment interplay implies differences in phenotypic...

[Neither the paper nor even the title of the paper seems to be available yet based on a quick search] https://www.eurekalert.org/news-releases/1084605 News Release 20-May-2025 Study finds alarming rates of anxiety and depression in children with long COVID Kennedy Krieger Institute research...

Immunological drivers and potential novel drug targets for major psychiatric, neurodevelopmental, and neurodegenerative conditions Christina Dardani, Jamie W. Robinson, Hannah J. Jones, Dheeraj Rai, Evie Stergiakouli, Jakob Grove, Renee Gardner, Andrew M. McIntosh, Alexandra Havdahl, Gibran...

An Alternative Approach to Future Diagnosis: Can Generalized Anxiety Disorder Be Distinguished From Major Depressive Disorder, Healthy People by Differentially Expressed lncRNAs in Peripheral Blood Lingming Kong, Liang Zhang [Line breaks added] Purpose Symptomatic diagnosis combined with...

Pediatric SARS-CoV-2 infection and development of anxiety and depression Dun-Dery, Frederick; Xie, Jianling; Zemek, Roger; Winston, Kathleen; Burstein, Brett; Sabhaney, Vikram; Emsley, Jason; Gravel, Jocelyn; Kam, April; Mater, Ahmed; Beer, Darcy; Porter, Robert; Freire, Gabrielle; Poonai...

The Association of Plasma Selenium and Selenoprotein P Levels with Depression Severity and Anxiety Symptoms Among Medical Students in Latvia Zanda Birģele, Paula Marija Vimba, Anastasija Ševčenko, Andrejs Šķesters, Gunta Ancāne, Laura Valaine Background and Objectives Oxidative stress has been...

Accelerated global burden of depressive disorders during the COVID-19 pandemic from 2019 to 2021 Jinlei Zhou, Yuan Zhang, Shuangshuang He, Sen Xu, Qice Sun, Tingxiao Zhao, Yaqin Dai [Line breaks added] Abstract A thorough and current analysis of the burden and evolving trends in depressive...

Blood Immuno-metabolic Biomarker Signatures of Depression and Affective Symptoms in Young Adults Nicholas Donnelly, Ruby Tsang, Èimear M Foley, Holly Fraser, Aimee Hanson, Golam M Khandaker Background Depression is associated with alterations in immuno-metabolic biomarkers, but it remains...

Long-COVID and postural orthostatic tachycardia syndrome: a preliminary comparison of neuropsychological performance Aitana Ruiz de Lazcano, Paula Pérez-Núñez, Mercè Pallarès-Sastre, Maddalen García-Sanchoyerto, Irune García, Imanol Amayra Purpose The aim of the study is to analyze and compare...

Investigating the Severity and Timeline of PASC Symptoms: Focus on Physiological and Cognitive Effects Rohan Melwani, Keerthana Noru, Sanya Kondapalli, Ameya Ravi, Saanvi Shah, Shreeya Setty, Shashank Sastry, Sahar Jahanikia [Preprint] Abstract The SARS-CoV-2 virus, responsible for the...

Abstract: Major depressive disorder (MDD) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) frequently occur together; yet their causal relationship remains unclear. To investigate the potential genetic causal link between these conditions, we conducted a two-sample Mendelian...

Immune Cell Exhaustion and Apoptotic Markers in Major Depressive Disorder: Effects of in Vitro Cannabidiol Administration. Muanpetch Rachayon, Ketsupar Jirakran, Pimpayao Sodsai, Chawit Tunvirachaisakul, Atapol Sughondhabirom, Yingqian Zhang, Jing Li, Michael Maes Background Immune...

No Abstract Provided My phone isn’t letting me copy exerpts from pdf. But the reason I’m sharing this is it’s a rather interesting peak into how pwME might be treated in China (it seems a diagnosis of “somatic depression” is likely). LINK (PDF)

Association of inflammation cytokines with cognitive function in first-episode major depressive disorder Yanfang Wang, Yanqing Xi, Zongqi Wang, Guojuan Li, Zhuoqun Hao, Jiahui Nie, Jinxiang Li, Yuting Tan, Xiaodong Hu, Genwei Wang, Sha Liu [Provisionally accepted] Abstract Abnormal cognitive...

Abstract: Sufficient evidence is now available to accept the concept that the brain recognizes cytokines as molecular signals of sickness. Clarifying the way the brain processes information generated by the innate immune system is accompanied by a progressive elucidation of the cellular and...