decodeme

I wanted to make a thread to discuss the theory that ME/CFS is a signaling problem, located in the synapses of neurons in the brain. I think it fits and would help explain the few findings and observations that we have about the illness. The clinical picture First of all, there is no clear...

Coming back up out of the detail we could really do with leveraging the Decode ME and other recent findings and working out a research roadmap which we could perhaps refine at the showcase event to develop the what next plan? Someone on the initial findings thread suggested developing a list of...

One of the candidate genes in the DecodeME preprint. Curcumin increases PRDX6 expression.

We have started this thread by splitting off some of the posts in the DecodeMe in the Media thread. The focus is what the community can do to maximise and make good use of the public interest, and to keep up momentum on research. ************************** So- as a priority- how can this...

Wanted to pull this out of the DecodeME discussion thread, for those who won't be looking at every message in what is quite a technical discussion!

HLA-DQA*05:01 Potential association from DecodeME:

DecodeME candidate ME gene From the Candidate Genes document CHROMOSOME 6p Chr6p contained seven Tier 1 genes. ******************** HFE (Tier 1) • Protein: Homeostatic iron regulator protein. UniProt. GeneCards. The allele that increases the risk of ME/CFS is associated with increasing HFE...

DecodeME candidate ME gene From the Candidate Genes document CHROMOSOME 20 Chr20 contained seven Tier 1 genes. *************** CSE1L (Tier 1) • Protein: Chromosome segregation 1-like (also known as exportin-2). UniProt. GeneCards. The allele that increases the risk of ME/CFS is associated...

DecodeME candidate ME gene From the Candidate Genes document CHROMOSOME 17 Chr17 contained one Tier 1 gene. **************** CA10 (Tier 1) • Protein: Carbonic anhydrase-related protein 10. UniProt. GeneCards. Note that this gene encodes a protein that lacks catalytic activity. The allele...

DecodeMe Candidate Gene CHROMOSOME 15 Chr15 contained no Tier 1 genes and one Tier 2 gene. ********************* CCPG1 (Tier 2) • Protein: Cell cycle progression 1. UniProt. GeneCards. • Molecular function: Involved in positive regulation of cell cycle and positive regulation of cell...

DecodeMe Candidate Gene CHROMOSOME 13 Chr13 contained no Tier 1 genes and one Tier 2 gene. ******************** OLFM4 (Tier 2) • Protein: Olfactomedin-4. UniProt. GeneCards. • Molecular function: OLFM4 facilitates cell adhesion, most probably through interaction with cell surface lectins...

DecodeMe Candidate Gene CHROMOSOME 12 (GWAS-2) Chr12 contained three Tier 1 genes. ******************** SUDS3 (Tier 1) • Protein: SIN3A corepressor complex component, also known as SDS3. UniProt. GeneCards. The allele that increases the risk of ME/CFS is associated with increased SUDS3...

DecodeME candidate ME/CFS gene ******************** FBXL4 (Tier 2) • Protein: F-box/LRR-repeat protein 4. UniProt. GeneCards. • Molecular function: Component of the mitochondria-localised SCF-FBXL4 ubiquitin E3 ligase complex. This complex restricts mitophagy by controlling the degradation...

DecodeME candidate ME/CFS gene CHROMOSOME 6p Chr6p contained seven Tier 1 genes. *************************** BTN2A2 (Tier 1) • Protein: Butyrophilin subfamily 2 member A2. UniProt. GeneCards. The allele that increases the risk of ME/CFS is associated with decreasing BTN2A2 gene expression...

From DecodeME Candidate Genes: RABGAP1L (Tier 1) • Protein: RAB GTPase-activating protein 1-like, also known as TBC1D18. UniProt. GeneCards. The allele that increases the risk of ME/CFS is associated with decreasing RABGAP1L gene expression. • Molecular function: GTP-hydrolysis activating...

The DecodeME site FAQs page has a donation link that goes here to an Action for ME website page that says: 'Help change lives. Help us build on the work of DecodeME by supporting future research into ME/CFS. Donations will be managed by Action for ME, and used towards research projects delivered...

Initial posts have been moved from DecodeME in the Media **************************************************************************** Science Media Centre (featuring Sour-Grapes Carson, of course)...

[Additional line breaks added] ABSTRACT Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) is a common, poorly understood disease that has no effective treatments, and has long been underserved by scientific research and national health systems. It is a sex-biased disease towards...

Shortened version– read the full blog here. Scientists, people with ME/CFS, and their charities came together to create DecodeME, the world's biggest ME/CFS study – and its results are striking. 18,000 people with ME/CFS gave their DNA, enabling DecodeME to reveal eight genetic signals for the...

This thread is for media and social media items about DecodeME following the release of the results, and for discussion about the media items. For the analysis of the DecodeME results, there will be a research thread for the paper which we will link here. Edit: The preprint thread here...