covid

A highly divergent sample from a nearly extinct SARS-CoV-2 lineage in a patient with long-term COVID-19 BACKGROUND Although COVID-19 is primarily an acute disease, there are cases of persistent infection, primarily in immunocompromised patients. It is hypothesized that at least some variants...

HLA-B*15:01-positive severe COVID-19 patients lack CD8+ T cell pools with highly expanded public clonotypes Understanding host factors driving asymptomatic versus severe disease outcomes is of key importance if we are to control emerging and re-emerging viral infections. HLA-B*15:01 has been...

The BMJ: Why scientists are rethinking the immune effects of SARS-CoV-2

Stress-induced translocation of the endoplasmic reticulum chaperone GRP78/BiP and its impact on human disease and therapy Lee; Amy S Since their discoveries in the 1960s as a family of proteins produced by cells in response to stress, molecular chaperones are increasingly recognized as major...

Ischaemic endothelial necroptosis induces haemolysis and COVID-19 angiopathy Wu, Mike C. L.; Italiano, Ethan; Jarvis-Child, Rocko; Alwis, Imala; Smythe, Rhyll; Albornoz, Eduardo A.; Noonan, Jonathan; Portelli, Marie; Baptista, Marissa; Maclean, Jessica; Noori, Pashtana; Yang, Jinglu; Lee, John...

Abstract COVID-19 vaccines have prevented millions of COVID-19 deaths. Yet, a small fraction of the population reports a chronic debilitating condition after COVID-19 vaccination, often referred to as post- vaccination syndrome (PVS). To explore potential pathobiological features associated with...

Prevalence and demographics of 331 rare diseases and associated COVID-19-related mortality among 58 million individuals: a nationwide retrospective observational study Johan H Thygesen; Huayu Zhang; Hanane Issa; Jinge Wu; Tuankasfee Hama; Ana-Caterina Phiho-Gomes; Tudor Groza; Sara Khalid...

Assessment of Myocardial 18F-FDG Uptake at PET/CT in Asymptomatic SARS-CoV-2–vaccinated and Nonvaccinated Patients Authors: Takehiro Nakahara et al Published Online: Sep 19 2023 Abstract Background Patients who developed myocarditis after SARS-CoV-2 vaccination show abnormalities on cardiac...

COVID 5 years later: Learning from a pandemic many are forgetting Five years after SARS-CoV-2 surfaced, scientists reflect and look ahead to the next threat https://www.science.org/content/article/covid-5-years-later-learning-pandemic-many-are-forgetting (I added some line breaks and bolding...

SARS-CoV-2 S1 subunit produces a protracted priming of the neuroinflammatory, physiological, and behavioral responses to a remote immune challenge: A role for corticosteroids Frank; Ball; Hopkins; Kelley; Kuzma; Thompson; Fleshner; Maier Long COVID is a major public health consequence of...

Altered spike IgG Fc N-linked glycans are associated with hyperinflammatory state in adult COVID and Multisystem Inflammatory Syndrome in Children Jacob D. Sherman; Vinit Karmali; Bhoj Kumar; Trevor W. Simon; Sarah Bechnak; Anusha Panjwani; Caroline R. Ciric; Dongli Wang; Chris Huerta; Brandi...

Preferential and sustained platelet activation in COVID-19 survivors with mental disorders Maugeri, Norma; De Lorenzo, Rebecca; Mazza, Mario Gennaro; Palladini, Mariagrazia; Ciceri, Fabio; Rovere-Querini, Patrizia; Manfredi, Angelo A.; Benedetti, Francesco Pre-existing mental disorders are...

SARS-CoV-2 spike protein potentiates platelet aggregation via upregulating integrin αIIbβ3 outside-in signaling pathway Wang, Ruijie; Tian, Zezhong; Zhu, Meiyan; Zhang, Bingying; Li, Yanzhang; Zheng, Yiqi; Mao, Yuheng; Zhao, Yimin; Yang, Yan Platelet hyperreactivity is one of the crucial causes...

TLR2/4 are novel activating receptors for SARS-CoV-2 spike protein on NK cells Landolina, Nadine; Ricci, Biancamaria; Veneziani, Irene; Alicata, Claudia; Mariotti, Francesca Romana; Pelosi, Andrea; Quatrini, Linda; Mortari, Eva Piano; Carsetti, Rita; Vacca, Paola; Tumino, Nicola; Azzarone...

From the #MEAction website: Questions to Ask Prospective MPs About ME/CFS https://www.meaction.net/2024/06/04/questions-to-ask-prospective-mps-about-me-cfs/

In communities of color, long-covid patients are tired of being sick and neglected Regular link: https://www.washingtonpost.com/health/2024/05/28/long-covid-patients-of-color-black-latino/ Gift link (no paywall for 2 weeks): https://wapo.st/3wSGcYO Further down in the article there's a quote...

An episode from Ground Truths, a podcast by Eric Topol: Svetlana Blitshteyn: On the Front Line With Long Covid and POTS https://erictopol.substack.com/p/svetlana-blitshteyn-on-the-front Episode is about 53 minutes long. Transcript included.

Extreme γ′ fibrinogen levels in COVID-19 patients Hudkins; Hamilton; Underwood; Kazmierczak; Dewey; Kazmierczak; Messer; Khan; Schreiber; Farrell COVID-19 disease progression can be accompanied by a “cytokine storm” that leads to secondary sequelae such as acute respiratory distress syndrome...

[I think this belongs here - please move if necessary] A Fight About Viruses in the Air Is Finally Over. Now It’s Time for Healthy Venting https://www.scientificamerican.com/article/a-fight-about-viruses-in-the-air-is-finally-over-now-its-time-for-healthy/

An amyloidogenic fragment of the SARS CoV-2 envelope protein promotes serum amyloid A misfolding and fibrillization Asal Nady; Sean E Reichheld; Simon Sharpe SARS CoV-2 infection can affect a surprising number of organs in the body and cause symptoms such as abnormal blood coagulation...