colitis

  1. Andy

    Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis, 2021, Hinrishsen et al

    [In mice]. Highlights • Loss of epithelial HK2 protects against acute intestinal inflammation • Ablation of HK2 suppresses cell death and dysregulates mitochondrial function • The microbiome regulates HK2 expression via SCFAs targeting HDAC8 • The SCFA butyrate ameliorates intestinal...
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