chronic pain

TRPM2 is a direct pain transducer Varghese, Linda; Alizada, Mujahid; Yang, Jinquan; Feng, Ye; Yuan, Xiaoqiu; Malhotra, Mitali; Zhang, Xuming Chronic pain results from maladaptive interaction between the immune and nervous systems. TRPM2 channels in immune cells (immune TRPM2) are believed to...

Orthopedic Risks and Recovery Considerations in Long COVID: A Narrative Review Abstract The COVID-19 pandemic left a lasting imprint on orthopedic surgery, initially through widespread reductions in care delivery and subsequently through the complex challenges posed by Long COVID syndrome...

Distinct multidimensional anger profiles predict current and long-term chronic pain outcomes Highlights • Latent profile analysis identified four distinct anger profiles in individuals with chronic pain. • Anger profiles associated with current and long-term outcomes, beyond anxiety and...

Phytochemical Modulators of Nociception: A Review of Cannabis Terpenes in Chronic Pain Syndromes Abstract Cannabis sativa L. is a phytochemically rich plant with therapeutic potential across various clinical domains, including pain, inflammation, and neurological disorders. Among its...

Paywalled. ////////////////////////////////////////// Anterior midcingulate cortex activity during pain catastrophizing predicts and sequentially tracks reduction in pain interference after cognitive behavioral therapy in fibromyalgia Abstract Abstract Fibromyalgia (FM) is a chronic pain...

Peak alpha frequency is associated with pain severity in Long COVID patients with new-onset chronic pain New-onset chronic pain is a common and debilitating symptom of Long COVID (LC) that remains not fully understood in terms of pathophysiology and therapeutic targets. A growing body of...

Abstract Primary sensory neurons in dorsal root ganglia (DRG) have long axons and a high demand for mitochondria, and mitochondrial dysfunction has been implicated in peripheral neuropathy after diabetes and chemotherapy1,2. However, the mechanisms by which primary sensory neurons maintain their...

https://www.nature.com/articles/s41586-025-09602-x Abstract Long-term sustained pain following acute physical injury is a prominent feature of chronic pain conditions1. Populations of neurons that rapidly respond to noxious stimuli or tissue damage have been identified in the spinal cord...

Diagnosis, Prognosis, and Drug Target Discovery for Chronic Widespread Pain: A Large Proteogenomic Study Li Chen, Eoin Kelleher, Ruogu Meng, Duanke Liu, Yuchen Guo, Yunhe Wang, Yaqing Gao, Zhe Huang, Zhu Liang, Shuai Yuan, Chao Zeng, Jun Ma, Yanhui Dong, Anushka Irani, Guanghua Lei, Junqing...

SLC45A4 is a pain gene encoding a neuronal polyamine transporter Polyamines are regulatory metabolites with key roles in transcription, translation, cell signalling and autophagy1. They are implicated in multiple neurological disorders, including stroke, epilepsy and neurodegeneration, and can...

Pain among US adults before, during, and after the COVID-19 pandemic: a study using the 2019 to 2023 National Health Interview Survey Zajacova, Anna; Grol-Prokopczyk, Hanna; Nahin, Richard L The unprecedented disruption of the COVID-19 pandemic raises crucial questions about its impact on...

Evidence for a role of skull bone marrow in human chronic pain as revealed by TSPO PET imaging The skull bone marrow is emerging as a critical hub for neuroimmune signaling in various disorders, with the potential to reshape how we understand brain-immune interactions. However, its role in...

https://www.msn.com/en-gb/health/other/chronic-pain-sufferers-find-relief-through-uk-first-treatment/ar-AA1IPVUq?ocid=msedgntp&pc=U531&cvid=a2f791a7ef594e72aba4a80c5c7a4ec3&ei=78 :borg:

https://www.science.org/doi/10.1126/sciadv.abc5219 A role for proprioceptors in sngception Cheng-Han Lee https://orcid.org/0000-0003-3642-4115, Jiann-Her Lin https://orcid.org/0000-0002-7255-741X, Shing-Hong Lin https://orcid.org/0000-0002-8012-6935, Chu-Ting Chang...

Pathogen-specific exposure is associated with multisite chronic pain: A prospective cohort study Jialiu Fang, Zemene Demelash Kifle, Jing Tian, Silvana Bettiol, Flavia Cicuttini, Graeme Jones, Feng Pan [Line breaks added] Abstract Evidence suggests that pathogens may influence pain perception...

Evidence for a Causal Association Between Human Cytomegalovirus Infection and Chronic Back Pain: A One‐Sample Mendelian Randomization Study Maryam Kazemi Naeini, Maxim B Freidin, Isabelle Granville Smith, Stephen Ward, Frances M K Williams Background Chronic back pain (CBP) is a major cause of...

Good in depth article—mentions fibromyalgia. https://www.nytimes.com/2025/01/12/magazine/chronic-pain.html?unlocked_article_code=1.ok4.Ggyl.jPE4qqT8991M&smid=url-share

Full title: Transcutaneous electrical nerve stimulation for fibromyalgia-like syndrome in patients with Long-COVID: a pilot randomized clinical trial Alejandro Zulbaran-Rojas, Rasha O. Bara, Myeounggon Lee, Miguel Bargas-Ochoa, Tina Phan, Manuel Pacheco, Areli Flores Camargo, Syed Murtaza...

Found this thread by Sabrina Porter on bluesky and though worth sharing. For rest see: https://bsky.app/profile/sabrinapoirier.bsky.social/post/3lcxcph4iec2l Thought she made some really good points. Except for the unproven mast cell and brain inflammation stuff at the end.

Background Chronic overlapping pain conditions (COPCs), pain-related conditions that frequently occur together, may occur in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and could impact illness severity. This study aimed to identify comorbid COPCs in patients with...