cgas-sting

Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender Excessive exercise impairs cognitive function, but the underlying mechanism remains unclear. Here, we show that excessive vigorous exercise-induced lactate accumulation stimulates muscles to...

An emerging role for calcium signalling in innate and autoimmunity via the cGAS-STING axis Mathavarajah, Sabateeshan; Salsman, Jayme; Dellaire, Graham Abstract Type I interferons are effector cytokines essential for the regulation of the innate immunity. A key effector of the type I interferon...

Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation The cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS)-cyclic GMP-AMP (cGAMP)-stimulator of interferon genes (STING) pathway mediates antiviral innate...

Metabolism and Innate Immunity Meet at the Mitochondria Bahat, A., MacVicar, T., & Langer, T Abstract Mitochondria are master regulators of metabolism and have emerged as key signalling organelles of the innate immune system. Each mitochondrion harbours potent agonists of inflammation...

Microvesicle-transferred mitochondria trigger cGAS-STING and reprogram metabolism of macrophages in sepsis Ji T, Zhao T, Long S, Wei C, Cheng D, Chen J, Kuang L Abstract The inflammatory cytokine storm is a hallmark of sepsis and is highly correlated with organ injury. Therefore, inhibiting...

Mitochondrial innate immune signaling in skeletal muscle adaptation to exercise Jin Ma; Annie Yujin Son; Youlim Son; Ping-yuan Wang; Paul M. Hwang Exercise-induced inflammation is regarded as a response to muscle damage from mechanical stress, but controlled immune signaling can be beneficial...

Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system (CNS), the pathophysiology of which remains unclear and for which there is no definitive cure. Antimicrobial peptides (AMPs) are immunomodulatory molecules expressed in various tissues, including the CNS...

Type I interferons and endoplasmic reticulum stress in health and disease Sprooten; Garg Type I interferons (IFNs) comprise of pro-inflammatory cytokines created, as well as sensed, by all nucleated cells with the main objective of blocking pathogens-driven infections. Owing to this broad range...

SARS-CoV-2 Mitochondrial Metabolic and Epigenomic Reprogramming in COVID-19 Guarnieri; Haltom; Albrecht; Lie; Olali; Widjaja; Ranshing; Angelin; Murdock; Wallace To determine the effects of SARS-CoV-2 infection on cellular metabolism, we conducted an exhaustive survey of the cellular metabolic...

Chloride Homeostasis Regulates cGAS-STING Signaling Jared Morse; Danna Wang; Serena Mei; Danielle Whitham; Colby Hladun; Costel C. Darie; Herman O Sintim; Modi Wang; KaHo Leung The cGAS-STING signaling pathway has emerged as a key mediator of inflammation. However, the roles of chloride...

Severe COVID-19 and long COVID are associated with high expression of STING, cGAS and IFN-α Queiroz, Maria Alice Freitas; Brito, Wandrey Roberto dos Santos; Pereira, Keise Adrielle Santos; Pereira, Leonn Mendes Soares; Amoras, Ednelza da Silva Graça; Lima, Sandra Souza; Santos, Erika Ferreira...