brainstem

  1. John Mac

    Preprint Hypothesis: A Mechanical Basis: Brainstem Dysfunction as a Potential Etiology of ME/CFS and Long COVID, 2025, Jeff Wood, Kaufman et al.

    Abstract The underlying pathologies driving post-acute infectious syndromes (e.g. myalgic encephalomyelitis / chronic fatigue syndrome, long COVID, etc) remain poorly understood. Given the extreme burden these illnesses impose on suffers, and the dramatic increase in cases following the COVID-19...
    • John Mac
    • Thread
    • brainstem immune system jeff wood kaufman long covid me/cfs peripheral nervous system remission biome
    • Replies: 49
    • Forum: ME/CFS research
  2. leokitten

    Brainstem Reduction and Deformation in the 4th Ventricle Cerebellar Peduncles in Long COVID Patients, 2025, Christof et al

    https://www.medrxiv.org/content/10.1101/2025.04.08.25325108 Abstract Post-COVID Syndrome (PCS), also known as Long COVID, is characterized by persistent and often debilitating neurological sequelae, including fatigue, cognitive dysfunction, motor deficits, and autonomic dysregulation (Dani et...
    • leokitten
    • Thread
    • brainstem cerebellum demyelination diffusion mri diffusion tensor imaging long covid myelin
    • Replies: 20
    • Forum: Long Covid research
  3. Mij

    Altered auditory brainstem responses are post-acute sequela of SARS-CoV-2 (PASC), 2025, Christopher Niemczak et al

    Abstract The Post-acute Sequela of SARS-CoV-2 (PASC) syndrome, also known as Long-COVID, often presents with subjective symptoms such as brain fog and cognitive fatigue. Increased tinnitus, and decreased hearing in noise ability also occur with PASC, yet whether auditory manifestations of PASC...
  4. forestglip

    ME/CFS and LC at International Society for Magnetic Resonance in Medicine 2024

    Assessment of Functional connectivity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome using 7Tesla MRI Maira Inderyas, Kiran Thapaliya, Sonya Marshall-Gradisnik, Markus Barth, and Leighton Barnden Motivation: To assess Functional Connectivity (FC) differences between healthy individuals...
    • forestglip
    • Thread
    • brainstem cerebellum fmri functional connectivity intrinsic network hubs venous oxygen saturation
    • Replies: 12
    • Forum: ME/CFS research
  5. forestglip

    BBC: How Long Concussion could offer new insights into Long Covid

    Link to article By David Cox
    • forestglip
    • Thread
    • brainstem inflammation long concussion long covid mitochondria psychedelics viral reactivations
    • Replies: 43
    • Forum: Long Covid news
  6. SNT Gatchaman

    Quantitative susceptibility mapping at 7 Tesla in COVID-19: mechanistic and outcome associations, 2023, Rua et al.

    Quantitative susceptibility mapping at 7 Tesla in COVID-19: mechanistic and outcome associations Catarina Rua; Betty Raman; Christopher T Rodgers; Virginia F J Newcombe; Anne Manktelow; Doris A Chatfield; Stephen J Sawcer; Joanne G Outtrim; Victoria C Lupson; Emmanuel A Stamatakis; Guy B...
  7. SNT Gatchaman

    Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions, 2020, Fransen et al.

    Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions Fransen, Nina L; Hsiao, Cheng-Chih; van der Poel, Marlijn; Engelenburg, Hendrik J; Verdaasdonk, Kim; Vincenten, Maria C J; Remmerswaal, Ester B M; Kuhlmann, Tanja; Mason, Matthew R J; Hamann...
  8. SNT Gatchaman

    [Preprint] The central nervous systems proteogenomic and spatial imprint upon systemic viral infections with SARS-CoV-2, 2023, Radke et al

    The central nervous systems proteogenomic and spatial imprint upon systemic viral infections with SARS-CoV-2 In COVID-19 neurological alterations are noticed during the systemic viral infection. Various pathophysiological mechanisms on the central nervous system (CNS) have been suggested in...
  9. SNT Gatchaman

    [Preprint] COVID-19 Neuropathology: evidence for SARS-CoV-2 invasion of Human Brainstem Nuclei, 2022, Emmi et al

    COVID-19 Neuropathology: evidence for SARS-CoV-2 invasion of Human Brainstem Nuclei Aron Emmi, Stefania Rizzo, Luisa Barzon, Michele Sandre, Elisa Carturan, Alessandro Sinigaglia, Silvia Riccetti, Mila della Barbera, Rafael Boscolo-Berto, Patrizia Cocco, Veronica Macchi, Angelo Antonini, Monica...
  10. Sly Saint

    Brainstem Abnormalities in [ME/CFS]: A Scoping Review and Evaluation of Magnetic Resonance Imaging Findings, 2021, Nelson et al

    Nelson T, Zhang LX, Guo H, Nacul L, Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a multisystem medical condition with heterogeneous symptom expression. Currently, there is no effective cure or treatment for the standard care of patients. A variety of ME/CFS...
  11. J

    Disruption of brainstem monoaminergic fibre tracts in multiple sclerosis as a putative mechanism for cognitive fatigue: a fixel-based analysis 2021

    Disruption of brainstem monoaminergic fibre tracts in multiple sclerosis as a putative mechanism for cognitive fatigue: a fixel-based analysis https://www.sciencedirect.com/science/article/pii/S2213158221000310?via=ihub Highlights • We compared monoaminergic fibre tracts integrity in...
  12. Andy

    Brainstem damage is associated with poorer sleep quality and increased pain in gulf war illness veterans, 2021, Zhang et al

    Abstract Aims Gulf War Illness (GWI) is manifested as multiple chronic symptoms, including chronic pain, chronic fatigue, sleep problems, neuropsychiatric disorders, respiratory, gastrointestinal, and skin problems. No single target tissue or unifying pathogenic process has been identified that...
  13. John Mac

    Open The ME-SH (ME in Stockholm-Harvard) Study: Structural Problems in Brainstem and Cervical Spine Cord in (ME/CFS) - a case control study 2021 Bragee

    Full title: The ME-SH (Myalgic Encephalomyelitis in Stockholm-Harvard) Study: Structural Problems in Brainstem and Cervical Spine Cord in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome(ME/CFS) - a Case-control Study Not yet recruiting...
  14. Andy

    Persistent Brainstem Dysfunction in Long-COVID: A Hypothesis, 2021, Shin Jie Yong

    Persistent Brainstem Dysfunction in Long-COVID: A Hypothesis Edited to shorter paragraphs for easier reading. Paywall, https://pubs.acs.org/doi/full/10.1021/acschemneuro.0c00793
  15. A

    Identification of a brainstem locus that inhibits tumour necrosis factor, 2020, Kressel et al

    From Twitter Paper from earlier this year
  16. Andy

    Grey and white matter differences in Chronic Fatigue Syndrome – A voxel-based morphometry study, 2018, Finkelmeyer et al

    Open access, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633338/
    • Andy
    • Thread
    • 2018 brainstem finkelmeyer grey matter me/cfs mri neuroimaging paper white matter
    • Replies: 0
    • Forum: ME/CFS research
  17. Andy

    Coexistence of cerebral hypometabolism and neuroinflammation in the thalamo-limbic-brainstem region in young women with FSS, 2020, Ouchi et al

    Full title: Coexistence of cerebral hypometabolism and neuroinflammation in the thalamo-limbic-brainstem region in young women with functional somatic syndrome Note: Due to vague selection criteria this may, or may not, be an investigation into ME. Open access...
    • Andy
    • Thread
    • 2020 brain imaging brainstem fss japan mus neuroinflammation ouchi paper pet scan
    • Replies: 3
    • Forum: ME/CFS research
  18. Andy

    Brainstem Atrophy in Gulf War Illness, 2020, Zhang et al

    Paywall, https://www.sciencedirect.com/science/article/abs/pii/S0161813X20300280 Sci hub, https://sci-hub.tw/10.1016/j.neuro.2020.02.006
  19. D

    Intra brainstem connectivity is impaired in chronic fatigue syndrome, Barnden et al., 2019

    https://www.sciencedirect.com/science/article/pii/S2213158219303924 Abstract:
    • Deleted member 3253
    • Thread
    • 2019 barnden brainstem me/cfs paper
    • Replies: 40
    • Forum: ME/CFS research
  20. Indigophoton

    Hyperintense sensorimotor T1 spin echo MRI is associated with brainstem abnormality in CFS, 2018, Barnden et al

    https://www.sciencedirect.com/science/article/pii/S2213158218302237
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