aquaporin

Asymmetrical glymphatic dysfunction in patients with long Covid associated neurocognitive impairment- correlation with BBB disruption Chaganti, Joga R.; Talekar, Tanush K.; Brew, Bruce James BACKGROUND AND PURPOSE The glymphatic system, a waste clearance pathway, has been implicated in several...

Full title: Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19 Rebeka Fekete, Alba Simats, Eduárd Bíró, Balázs Pósfai, Csaba Cserép, Anett D. Schwarcz, Eszter Szabadits, Zsuzsanna Környei, Krisztina...

Repetitive Low-Level Blast Exposure Alters Circulating Myeloperoxidase, Matrix Metalloproteinases, and Neurovascular Endothelial Molecules in Experienced Military Breachers Rhind, Shawn G.; Shiu, Maria Y.; Tenn, Catherine; Nakashima, Ann; Jetly, Rakesh; Sajja, Venkata Siva Sai Sujith; Long...

Abstract COVID-19 vaccines have prevented millions of COVID-19 deaths. Yet, a small fraction of the population reports a chronic debilitating condition after COVID-19 vaccination, often referred to as post- vaccination syndrome (PVS). To explore potential pathobiological features associated with...

Brain cerebral blood flow with MRI-visible enlarged perivascular space in adults Chunyan Yu; Baijie Wang; Qiyuan Sun; Huiyan Huo; Lingyan Zhang; Du Hongyan OBJECTIVES To explore the correlation between enlarged perivascular spaces (EPVS) in the basal ganglia (BG-EPVS) and centrum semiovale...

Aquaporins: Gatekeepers of Fluid Dynamics in Traumatic Brain Injury Czyżewski, Wojciech; Litak, Jakub; Sobstyl, Jan; Mandat, Tomasz; Torres, Kamil; Staśkiewicz, Grzegorz Aquaporins (AQPs), particularly AQP4, play a crucial role in regulating fluid dynamics in the brain, impacting the...

Waste Clearance in the Brain Kaur, Jasleen; Fahmy, Lara M.; Davoodi-Bojd, Esmaeil; Zhang, Li; Ding, Guangliang; Hu, Jiani; Zhang, Zhenggang; Chopp, Michael; Jiang, Quan Waste clearance (WC) is an essential process for brain homeostasis, which is required for the proper and healthy functioning...

Abstract The accumulation of metabolic waste is a leading cause of numerous neurological disorders, yet we still have only limited knowledge of how the brain performs self-cleansing. Here we demonstrate that neural networks synchronize individual action potentials to create large-amplitude...

Complement in neurological disorders and emerging complement-targeted therapeutics Dalakas, Marinos C.; Alexopoulos, Harry; Spaeth, Peter J. The complement system consists of a network of plasma and membrane proteins that modulate tissue homeostasis and contribute to immune surveillance by...

Abstract During maximal exercise healthy humans increase their oxygen uptake (V̇O2) 10 to 20-fold that measured at rest to as much as 6 L/min. At the molecular level the numbers are staggering: Each minute the exercising O2 transport system - lungs, cardiovascular and active muscles – must...