anterior cingulate cortex

Astrogliosis Marker [11C]SL25.1188 After COVID-19 With Ongoing Depressive and Cognitive Symptoms Background After acute COVID-19, 5% of people experience persistent depressive symptoms and reduced cognitive function (COVID-DC). Theoretical models propose that astrogliosis is important in long...

Dynamic multivariate patterns of brain structure–neuropsychiatric symptom associations in long COVID Abstract Long COVID presents with heterogeneous and persistent neuropsychiatric symptoms, suggesting possible shared neural underpinnings. However, the dynamic brain structure–symptom...

Investigation of BOLD signal intensities in long COVID patients using 7T functional MRI Abstract Long COVID is increasingly associated with disruption in brain homeostasis, manifesting as severe neurological dysfunction, brain fog and cognitive impairment. This present study investigated...

Biological Insights from Genome-Wide Association Studies and Whole Genome Sequencing of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Maccallini, Paolo Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disorder of poorly understood etiology. We...

Post COVID-19 condition is associated with altered regional cerebral blood volume as revealed by dynamic susceptibility contrast MRI BACKGROUND Coronavirus disease 2019 (COVID-19) has been associated with central nervous system dysfunction implicating cerebrovascular and neurovascular units...

IFN-Alpha-Induced Cortical and Subcortical Glutamate Changes Assessed by Magnetic Resonance Spectroscopy Abstract Cytokine effects on behavior may be related to alterations in glutamate metabolism. We therefore measured glutamate concentrations in brain regions shown to be affected by...

Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling The major anxiety disorders (ANX; including generalized anxiety disorder, panic disorder and phobias) are highly prevalent, often onset early and...

Key Points Question What is the prevalence of central sensitization syndrome in postural tachycardia syndrome (POTS)? Findings This case-control study of 305 patients found a high prevalence (86.5%) of central sensitization syndrome in individuals with POTS. Meaning These findings suggest...

Preprint. See post #6 for peer-reviewed version. Multimodal imaging suggests potential immune-vascular contributions to altered regional brain perfusion and oxygen metabolism in Post-COVID-19 Syndrome Post-COVID-19 Syndrome (PCS) frequently presents with persistent fatigue, cognitive...

Abstract: Background Post-COVID condition (PCCo) affects 5-10% of individuals following SARS-CoV-2 infection, with cognitive disturbances being a major feature. Central hypotheses regarding its pathophysiology include disturbed cell energy metabolism and oxidative stress pointing to...

Disentangling nature and nurture: Exploring the genetic background of depressive symptoms in the absence of recent stress exposure using a GWAS approach Berta Erdelyi-Hamza, Dora Torok, Sandor Krause, Nora Eszlari, Gyorgy Bagdy, Gabriella Juhasz, Xenia Gonda Highlights • Heterogeneity of...