Exploring Hypercoagulability in Post-COVID Syndrome PCS: An Attempt at Unraveling the Endothelial Dysfunction
Muys, Maxim; Demulder, Anne; Besse-Hammer, Tatiana; Ghorra, Nathalie; Rozen, Laurence
BACKGROUND
The lingering effects of SARS-CoV-2 infection, collectively known as post-COVID syndrome...
Abstract
Background: Neuropsychiatric symptoms are prominent and can have a substantial functional impact in many people with Long COVID (LC). The underlying pathophysiology of neuropsychiatric LC (N-LC) is unknown.
Methods: 28 individuals with acute COVID-19 (AC), 50 N-LC (new or worsening...
Abstract
Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown1 to be highly efficient for discovery of genetic associations2. Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who...
Analysis of thrombogenicity under flow reveals new insights into the prothrombotic state of patients with post-COVID syndrome
Adela Constantinescu-Bercu, Anna Kessler, Rens de Groot, Bertina Dragunaite, Melissa Heightman, Toby Hillman, Laura C. Price, Ewan Brennan, Raphael Sivera, Karen...
Abstract
Background
Prolonged recovery is common after SARs-CoV-2 infection, however the pathophysiological mechanisms underpinning Long COVID syndrome remain unknown. VWF-ADAMTS13 imbalance, dysregulated angiogenesis and immuno-thrombosis are hallmarks of acute COVID-19. We hypothesized that...
Key Points
VWF(Ag):ADAMTS13 ratio ≥1.5 was evident in 28% of PCS cohort
55% of patients with impaired exercise capacity had a raised VWF(Ag):ADAMTS13 ratio ≥1.5 (OR 4)
Post-COVID syndrome (PCS) or Long-COVID is an increasingly recognised complication of acute SARS-CoV-2 infection...
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.