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  1. viyer05

    Long X STEM Directory (ME folks with STEM backgrounds/careers)

    Are you an ME, Long Covid, or other 'Long X' patient with a STEM background and/or career? If so, the volunteers (including myself) behind the Long X STEM Directory would welcome to list you there. This directory is a public resource of Long X patient stakeholders (patients & their...
  2. viyer05

    Neurovascular Dysregulation and Acute Exercise Intolerance in ME/CFS: A Randomized, Placebo-Controlled Trial of Pyridostigmine, 2022, Systrom et al

    Thank you for sharing your experience. I'm almost one week into my own n=1 beneficial experience. I was starting to have muscle weakness in addition to other ME symptoms, and Mestinon seemed to immediately improve that aspect: I have more spring in step & arm strength when I am upright. I...
  3. viyer05

    Skewing of the B cell receptor repertoire in myalgic encephalomyelitis/chronic fatigue syndrome, 2021, Sato et al

    When you say "underwhelming" @Jonathan Edwards, are you referencing the anti-idiotype hypothesis specifically or the broader B-cell repertoire story? There's some fresh high-profile (paywalled Nature) evidence for the same sort of "bad associative memory" situation you describe with Celiac for...
  4. viyer05

    Skewing of the B cell receptor repertoire in myalgic encephalomyelitis/chronic fatigue syndrome, 2021, Sato et al

    Speaking of meta @Hutan, I learned a lot about anti-idiotypic antibodies from reading this article peppered with Greek philosophy. Turns out the rabbit hole only goes so deep before Le Chatelier's principle forces an equilibrium. It makes me start to imagine ME/CFS as perhaps the "wrong"...
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