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  1. LarsSG
    Post

    Increased von Willebrand and Factor VIII plasma levels in gynecologic patients with Post-Acute-COVID-Sequela (PASC)/Long COVID, 2024, Bellone et al

    Perhaps of interest: Von Willebrand factor propeptide in severe coronavirus disease 2019 (COVID-19): evidence of acute and sustained endothelial...
    Post by: LarsSG, Jan 10, 2024 in forum: Long Covid research
  2. LarsSG
    Post

    Open Investigating the presence of Micro Clots and other blood factors in people with ME/CFS, Sheffield, Caroline Dalton

    Does anyone know which parameters they were looking at in blood (@chillier)? Given the results in Increased von Willebrand and Factor VIII plasma...
    Post by: LarsSG, Jan 9, 2024 in forum: Recruitment into current ME/CFS research studies
  3. LarsSG
    Post

    Increased von Willebrand and Factor VIII plasma levels in gynecologic patients with Post-Acute-COVID-Sequela (PASC)/Long COVID, 2024, Bellone et al

    Pretorius & Kell did report elevated VWF in Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19, though...
    Post by: LarsSG, Jan 9, 2024 in forum: Long Covid research
  4. LarsSG
    Post

    Increased von Willebrand and Factor VIII plasma levels in gynecologic patients with Post-Acute-COVID-Sequela (PASC)/Long COVID, 2024, Bellone et al

    Significant differences: [ATTACH] And maintained over a couple years: [ATTACH] But a very small cohort and even fewer controls, 60% with...
    Post by: LarsSG, Jan 9, 2024 in forum: Long Covid research
  5. LarsSG
    Thread

    Increased von Willebrand and Factor VIII plasma levels in gynecologic patients with Post-Acute-COVID-Sequela (PASC)/Long COVID, 2024, Bellone et al

    Stefania Bellone, Eric R. Siegel, David E. Scheim, Alessandro D. Santin Highlights Growing evidence suggests that persistent microvascular...
    Thread by: LarsSG, Jan 9, 2024, 7 replies, in forum: Long Covid research
  6. LarsSG
    Post

    Muscle abnormalities worsen after post-exertional malaise in long COVID, 2023/4, Wüst, van Vugt, Appelman et al

    Discussing this on Twitter so I made a plot showing the individual changes (I've removed one LC patient who didn't have both baseline and PEM...
    Post by: LarsSG, Jan 7, 2024 in forum: Long Covid research
  7. LarsSG
    Post

    Muscle abnormalities worsen after post-exertional malaise in long COVID, 2023/4, Wüst, van Vugt, Appelman et al

    This paper seems like it might be relevant to the amyloid in muscle question: TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle...
    Post by: LarsSG, Jan 6, 2024 in forum: Long Covid research
  8. LarsSG
    Post

    Muscle abnormalities worsen after post-exertional malaise in long COVID, 2023/4, Wüst, van Vugt, Appelman et al

    They did see the amyloid deposits (or whatever they might be staining with Thioflavin T) in LC before exercise. Not really a huge change after...
    Post by: LarsSG, Jan 6, 2024 in forum: Long Covid research
  9. LarsSG
    Post

    Study Reveals Paxlovid Does Little to Stave Off Long COVID

    One of fatigue, shortness of breath, confusion, headache, altered taste and smell, joint pain, muscle aches, cough, chest pain, scratchy throat,...
    Post by: LarsSG, Jan 5, 2024 in forum: Long Covid news
  10. LarsSG
    Post

    Trial Report A cross-sectional study exploring the relationship between symptoms of anxiety/depression and P50 sensory gating in adults with CFS/ME, 2023, Liu

    Apparently, these are two different groups, based on some kind of EEG data from a sound repeated 100ms later. Supposedly, these two figures are...
    Post by: LarsSG, Jan 5, 2024 in forum: ME/CFS research
  11. LarsSG
    Post

    T4 apoptosis in the acute phase of SARS-CoV-2 infection predicts long COVID, 2024, Renaud Cezar et al

    This looks like they went on a fishing expedition by comparing all kinds of things and found one variable that was different. Yes, it looks like...
    Post by: LarsSG, Jan 5, 2024 in forum: Long Covid research
  12. LarsSG
    Post

    Muscle abnormalities worsen after post-exertional malaise in long COVID, 2023/4, Wüst, van Vugt, Appelman et al

    The absolute increase in amyloid-containing deposits after exercise testing was similar between controls and patients, which suggests maybe there...
    Post by: LarsSG, Jan 4, 2024 in forum: Long Covid research
  13. LarsSG
    Post

    Heterogenous circulating miRNA changes in ME/CFS converge on a unified cluster of target genes: A computational analysis, 2023, Kaczmarek

    Of the 14 genes identified in Precision Life's ME/CFS paper, only PHACTR2 meets the threshold in this paper (associated with 5 circulating...
    Post by: LarsSG, Jan 3, 2024 in forum: ME/CFS research
  14. LarsSG
    Post

    The Costs of Long COVID, 2022, Cutler

    The author has updated his cost estimate in this PDF, mostly based on ME/CFS. [ATTACH] He assumes people with 3+ LC symptoms are at 0.71 QALY for...
    Post by: LarsSG, Jan 3, 2024 in forum: Long Covid research
  15. LarsSG
    Post

    Heterogenous circulating miRNA changes in ME/CFS converge on a unified cluster of target genes: A computational analysis, 2023, Kaczmarek

    I'm not sure I'm understanding this correctly, but I think the hypothesis here is: A variety of circulating miRNAs are elevated in ME patients'...
    Post by: LarsSG, Jan 3, 2024 in forum: ME/CFS research
  16. LarsSG
    Post

    Ventricular cerebrospinal fluid lactate is increased in [CFS] compared with generalized anxiety disorder, 2009, Mathew et al.

    Looks like they only found high lactate in roughly half of the patients: [ATTACH] Maybe this would be one to test in a PEM state (ideally PEM...
    Post by: LarsSG, Jan 1, 2024 in forum: ME/CFS research
  17. LarsSG
    Post

    Trial Report Cost-Effectiveness of Online CBT for Children with CFS/ME Compared to Online Activity Management: FITNET-NHS Trial Findings, 2023, Crawley

    NICE says an intervention should be below £20,000 - £30,000 per QALY gained to be cost effective. So their approach is very much aimed at getting...
    Post by: LarsSG, Dec 30, 2023 in forum: Psychosomatic research - ME/CFS and Long Covid
  18. LarsSG
    Post

    Trial Report Cost-Effectiveness of Online CBT for Children with CFS/ME Compared to Online Activity Management: FITNET-NHS Trial Findings, 2023, Crawley

    You might be right. They say they adjusted for "baseline utility for QALYs", but that could also mean they adjusted between the groups to balance...
    Post by: LarsSG, Dec 30, 2023 in forum: Psychosomatic research - ME/CFS and Long Covid
  19. LarsSG
    Post

    Trial Report Cost-Effectiveness of Online CBT for Children with CFS/ME Compared to Online Activity Management: FITNET-NHS Trial Findings, 2023, Crawley

    Hard to know exactly what they are claiming from the poster, but it looks like they are just looking at one year, in which case a 0.53 QALY gain...
    Post by: LarsSG, Dec 30, 2023 in forum: Psychosomatic research - ME/CFS and Long Covid
  20. LarsSG
    Post

    Cardiopulmonary and hematological effects of infrared LED photobiomodulation in the treatment of SARS-COV2, 2023, Pereira et al

    I think blinding would be a significant issue with the IR LEDs too. Looking up the specs for the LEDs they used, each one is 0.135W x 300 LEDs =...
    Post by: LarsSG, Dec 30, 2023 in forum: Epidemics (including Covid-19, not Long Covid)
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