1. Sign our petition calling on Cochrane to withdraw their review of Exercise Therapy for CFS here.
    Dismiss Notice
  2. Guest, the 'News in Brief' for the week beginning 15th April 2024 is here.
    Dismiss Notice
  3. Welcome! To read the Core Purpose and Values of our forum, click here.
    Dismiss Notice

Search Results

Search Again
Page 1 of 9
  1. chillier
    Post

    The Netherlands - €28.5 million ME/CFS research program - ZonMW funding awards announced April 2023

    I gather there are ways of doing this on genomic data that are not based on related individuals. There's one way that exploits linkage...
    Post by: chillier, Apr 17, 2024 at 3:35 PM in forum: ME/CFS research news
  2. chillier
    Post

    MECFS data analysis thread

    1) Thank you! I'm glad you think so :) 2) I think that's basically right, just because the ones they agree on are not significant after multiple...
    Post by: chillier, Mar 30, 2024 in forum: Other research methodology topics
  3. chillier
    Post

    Post-Exertional Malaise - a discussion including defining and measuring PEM

    My understanding is the biggest parameter change is not VO2max, but a reduction in Ventilatory Threshold: The elbow where VCO2 begins to rapidly...
    Post by: chillier, Mar 27, 2024 in forum: Post-Exertional malaise and fatigue
  4. chillier
    Post

    Muscle oxygenation [as assessed by NIRS - Near Infra-Red Spectroscopy]

    Interesting @Hutan and @SNT Gatchaman. Trying to get my head around what you're both saying correct me if I'm misunderstanding. [O2HbMb]-[HHbMb]...
    Post by: chillier, Mar 26, 2024 in forum: Cardiovascular and exercise physiology (CPET)
  5. chillier
    Post

    MECFS data analysis thread

    Thank you :) They didn't do an analysis where they compared multiple datasets (from different papers). I mean that at baseline in their two day...
    Post by: chillier, Mar 25, 2024 in forum: Other research methodology topics
  6. chillier
    Post

    MECFS data analysis thread

    I've checked here using a linear model whether there is evidence for a given metabolite, that the two studies disagree in their fold change...
    Post by: chillier, Mar 25, 2024 in forum: Other research methodology topics
  7. chillier
    Post

    MECFS data analysis thread

    This makes sense about the metabolomics done at baseline but I think the two studies Hanson's group did across 4 time points over two CPETs are...
    Post by: chillier, Mar 22, 2024 in forum: Other research methodology topics
  8. chillier
    Post

    MECFS data analysis thread

    Is this comparing the significant metabolites from at least one study? Or is it comparing all of the detected metabolites regardless of whether...
    Post by: chillier, Mar 22, 2024 in forum: Other research methodology topics
  9. chillier
    Post

    Plasma metabolomics reveals disrupted response and recovery following maximal exercise in ME/CFS, Arnaud Germain, Maureen R. Hanson et al, 2022

    [ATTACH] In this figure panel they report on one of the top 2 significant metabolites associated with the difference between the first and second...
    Post by: chillier, Mar 14, 2024 in forum: ME/CFS research
  10. chillier
    Post

    Plasma metabolomics reveals disrupted response and recovery following maximal exercise in ME/CFS, Arnaud Germain, Maureen R. Hanson et al, 2022

    I wanted to make a post about this paper I think it's quite interesting. I like that by having a 4 time points and a longitudinal, paired design...
    Post by: chillier, Mar 14, 2024 in forum: ME/CFS research
  11. chillier
    Post

    Plasma metabolomics reveals disrupted response and recovery following maximal exercise in ME/CFS, Arnaud Germain, Maureen R. Hanson et al, 2022

    I love this! I was having a look through this data anyway and a resource like this would make it so much easier! It would be great (if and when...
    Post by: chillier, Mar 14, 2024 in forum: ME/CFS research
  12. chillier
    Post

    A map of metabolic phenotypes in patients with myalgic encephalomyelitis/chronic fatigue syndrome, 2021, Fluge, Mella et al

    It's interesting to see strong positive agreement about gamma-glutamylated amino acids (glutamate, lysine, tryptophan etc) in @Murph 's...
    Post by: chillier, Mar 14, 2024 in forum: ME/CFS research
  13. chillier
    Post

    A map of metabolic phenotypes in patients with myalgic encephalomyelitis/chronic fatigue syndrome, 2021, Fluge, Mella et al

    This is cool I have a lot of thoughts about this. First thing is Hoel 2021 use serum and Germain 2018 use plasma. The metabolomes of serum and...
    Post by: chillier, Mar 14, 2024 in forum: ME/CFS research
  14. chillier
    Post

    Opinion: ‘You don’t want to get better’: the outdated treatment of ME/CFS patients is a national scandal - George Monbiot

    Great article! George Monbiot is a very good ally
    Post by: chillier, Mar 12, 2024 in forum: General ME/CFS news
  15. chillier
    Post

    Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome, 2024, Walitt et al

    Thanks for this analysis Murph! Are these metabolites here significantly different in Baraniuk 2021? I had a quick skim but in the body of the...
    Post by: chillier, Mar 10, 2024 in forum: ME/CFS research
  16. chillier
    Post

    Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome, 2024, Walitt et al

    I noticed that in the NIH paper some of the p values they report for their metabolites are higher than their adjusted p values. This doesn't make...
    Post by: chillier, Mar 10, 2024 in forum: ME/CFS research
  17. chillier
    Post

    Pre-Illness Data reveals Differences in Multiple Metabolites and Metabolic Pathways in Those Who Do and Do Not Recover from IM, 2022, Jason et al

    Urea cycle: Carbamoyl phosphate synthesis is the rate limiting step of the urea cycle, it's formed from the combination of ammonia and...
    Post by: chillier, Mar 6, 2024 in forum: ME/CFS research
  18. chillier
    Post

    Pre-Illness Data reveals Differences in Multiple Metabolites and Metabolic Pathways in Those Who Do and Do Not Recover from IM, 2022, Jason et al

    Oh yeah very good point. I haven't gone into that myself but if @LarsSG is right about this that's reassuring. To me it looks like maybe three...
    Post by: chillier, Mar 6, 2024 in forum: ME/CFS research
  19. chillier
    Post

    Pre-Illness Data reveals Differences in Multiple Metabolites and Metabolic Pathways in Those Who Do and Do Not Recover from IM, 2022, Jason et al

    [ATTACH] Spermidine is the second most significant hit in the NIH intramural study's metabolomic data, as well as other polyamine related...
    Post by: chillier, Mar 6, 2024 in forum: ME/CFS research
  20. chillier
    Post

    Pre-Illness Data reveals Differences in Multiple Metabolites and Metabolic Pathways in Those Who Do and Do Not Recover from IM, 2022, Jason et al

    Viewing the whole thing as a heatmap might be easier: [ATTACH]
    Post by: chillier, Mar 5, 2024 in forum: ME/CFS research
Showing results 1 to 20 of 174 Next >
Search Again
Page 1 of 9