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Abstract Post-translational modifications (PTMs) regulate protein structure, function, and interactions, playing pivotal roles in cellular processes and disease progression. Lactate, a byproduct of the Warburg effect, accumulates excessively during viral infections and functions as a signaling...

Abstract Influenza causes 3–5 million severe cases globally each year, with severe viral pneumonia often requiring hospitalization for over four weeks. While the inflammatory response to influenza infection helps control viral replication, excessive inflammation is a key driver of disease...

Highlights • PSMB8 is induced in neurons under inflammatory conditions, such as multiple sclerosis • The integration of PSMB8 into the proteasome reduces proteasome activity in neurons • This causes the accumulation of PFKFB3, triggering a metabolic switch and ferroptosis • Targeting PSMB8 or...

Like many of my colleagues who care for patients with dysautonomia, chronic fatigue syndrome, and infection-associated chronic illness, I stumbled into this work seemingly by accident. As a rheumatology fellow, I was trained to ask sharp, targeted questions to diagnose rheumatic diseases. When...

Full title: ATP Supply from Cytosol to Mitochondria Is an Additional Role of Aerobic Glycolysis to Prevent Programmed Cell Death by Maintenance of Mitochondrial Membrane Potential Abstract Eukaryotic cells generate ATP primarily via oxidative and substrate-level phosphorylation. Despite the...

Full title: The Association Between COVID-19-Related Persistent Symptoms, Psychological Flexibility, and General Mental Health Among People With and Without Persistent Pain in the UK Abstract Objectives: Persistent symptoms following COVID-19 may adversely impact the general mental health of...

No, I won't see tags for threads that I can't see. I appreciate that it won't be helpful to you but I won't be revealing how much notice will be given.

Why, what difference does it make?

Abstract Lactate is a critical regulator of cellular processes and immune signaling, and we hypothesize that exercise-induced elevations in lactate help activate immune cells in response to vigorous exercise. Despite its importance, the impact of lactate on T-cell mitochondrial respiration...

Highlights Causal complexity characterises persistent physical symptoms (PPS) disproportionate to disease. The Symptoms Clinic Intervention recognises the reality of PPS and co-constructs explanations. Causal dispositionalism offers a second order explanatory vocabulary for complex singular...

Abstract Objective: Earlier research on fatigue in post-COVID-19 condition (PCC) has mainly studied subjective fatigue, either over a prolonged period (trait fatigue) or in relation to a certain situation (state fatigue) in the form of perceived fatigability. Another aspect of state fatigue...

Abstract Objective: To examine the development of different dimensions of fatigue and subjective and objective measures of sleep in the first 18 months post moderate to severe traumatic brain injury (TBI), and explore the association with biological (processing speed), psychological (mood), and...

Summary Background Despite the rapid increase in evidence from the past decade on daily steps and health-related outcomes, existing systematic reviews primarily focused on few outcomes, such as all-cause mortality. This study synthesised the prospective dose-response relationship between daily...

Highlights SSD patients exhibited greater reductions in somatic symptoms over 6 months compared to controls. Somatic symptoms were related to anxiety and trait anger, particularly in females. An interaction between anxiety and trait anger contributed to symptom severity. Reductions in anxiety...

"The term “imposter participants” has been proposed to characterise individuals who, for the purpose of participating in research, provide false identities and experiences [1-4]. The term ‘Inauthentic participants’ is a broader term which describes individuals or technologies that engage in...

Because those people who did express such reservations weren't listened to; once that was apparent then I didn't continue to waste my precious energy on pointless actions, especially as I have more productive things to focus on.

Yep, I can confirm this had nothing to do with the government.

Podcast: Invisible Battles: The Unseen Realities of Neurological Conditions "Welcome to another episode of Brain Health Matters, brought to you by the European Federation of Neurological Associations. In this episode, we’re shining a light on something often overlooked but deeply impactful—the...

Some very odd word choice, "CBT was either dominated by usual care" and "PEP dominated CBT" Perhaps AI 'helped' out?

"Acknowledgements The authors would like to thank Helen Dawes, Vincent Deary, Julia Newton, Kate Fryer, Samantha McCormick, David Coyle and Shijie Ren who contributed to the design of the research and specification of the review protocol."