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  1. Chris Ponting
    Post

    Patient and Public Involvement opportunities in ME/CFS and other research

    Thank you @Andy . A request for 2 PPI members: ยท ME/CFS-related Immune Research Project based at Imperial College. Proposal not currently...
    Post by: Chris Ponting, Sep 8, 2023 in forum: ME/CFS research
  2. Chris Ponting
    Post

    Could Some Patients With Fibromyalgia Potentially Have Hypophosphatasia? A Retrospective Single-Center Study 2023 Injean et al

    Thanks. We've looked in UK Biobank data and don't see low alkaline phosphatase levels on average. If anything it might be slightly higher.
    Post by: Chris Ponting, Sep 8, 2023 in forum: 'Conditions related to ME/CFS' news and research
  3. Chris Ponting
    Post

    Closed UK: DecodeME updates, was recruitment thread.

    Next steps for genetics are: (1) Replication in an independent cohort, (2) Joining forces with other projects to do a meta-analysis and (3)...
    Post by: Chris Ponting, Jun 29, 2023 in forum: Recruitment into current ME/CFS research studies
  4. Chris Ponting
    Post

    Locus for severity implicates CNS resilience in progression of multiple sclerosis, 2023, MS consortia

    Variant rs10191329 (minor allele frequency 17%) near to genes DYSF and ZNF638: p = 9.7x10-9 (whereas the usual significance threshold is...
    Post by: Chris Ponting, Jun 29, 2023 in forum: Other health news and research
  5. Chris Ponting
    Post

    Closed UK: DecodeME updates, was recruitment thread.

    We still need many more people. In part this is because we don't receive samples for all people sent a kit. The rate of sample kit returns is...
    Post by: Chris Ponting, Jun 28, 2023 in forum: Recruitment into current ME/CFS research studies
  6. Chris Ponting
    Post

    Thesis Thesis: Investigating the Genetic and Immunological Aetiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 2022 Dibble

    Unfortunately, when we asked 23andMe for their help (using their date), the male PDE10A signal did not replicate. So we need to look again once we...
    Post by: Chris Ponting, Feb 6, 2023 in forum: ME/CFS research
  7. Chris Ponting
    Post

    Genetic association study in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) identifies several potential risk loci, 2022,Hajdarevic et al

    And a (time-limited) link to the published version of this blog is here: https://authors.elsevier.com/a/1fFlT_KDvPN8-W
    Post by: Chris Ponting, Jun 22, 2022 in forum: ME/CFS research
  8. Chris Ponting
    Post

    The Occurrence of Hyperactivated Platelets and Fibrinaloid Microclots in ME/CFS, 2022, Nunes, Pretorius et al

    I asked Douglas Kell about this striking elevated level of % Area Amyloid for type 2 diabetes (relative to controls). He agreed that they had seen...
    Post by: Chris Ponting, Jun 13, 2022 in forum: ME/CFS research
  9. Chris Ponting
    Post

    The Occurrence of Hyperactivated Platelets and Fibrinaloid Microclots in ME/CFS, 2022, Nunes, Pretorius et al

    Hi Jonathan. I asked Doug Kell about this specifically, and he said that the experimentalists were blinded to case/control status.
    Post by: Chris Ponting, Jun 11, 2022 in forum: ME/CFS research
  10. Chris Ponting
    Post

    Genetic Risk Factors of ME/CFS: A Critical Review. Joshua J Dibble, Simon J McGrath, Chris P Ponting. 2020

    Joshua, Simon and I also wrote a slightly more accessible version which is available here:...
    Post by: Chris Ponting, Aug 3, 2020 in forum: ME/CFS research
  11. Chris Ponting
    Post

    DecodeME - UK ME/CFS DNA study underway

    There are so many people who made today's announcement the success that it has been, esp @Andy @Simon M Sonya, the charities, the funders and our...
    Post by: Chris Ponting, Jun 23, 2020 in forum: ME/CFS research news
  12. Chris Ponting
    Post

    Severity of Acute Infectious Mononucleosis Correlates with Cross-Reactive Influenza CD8 T-Cell Receptor Repertoires Nuray Aslan et al 2017

    Thanks. I don't think this was replicated by Jackie Cliff et al. : https://www.frontiersin.org/articles/10.3389/fimmu.2019.00796/full
    Post by: Chris Ponting, Apr 21, 2020 in forum: Other health news and research
  13. Chris Ponting
    Post

    Autoimmunity-Related Risk Variants in PTPN22 and CTLA4 Are Associated With ME/CFS With Infectious Onset (2020) Scheibenbogen et al.

    The Editor would request proof that these SNPs are not associated. Trying to prove a negative is a fool's errand! I do hope that the MEBiomed...
    Post by: Chris Ponting, Apr 12, 2020 in forum: ME/CFS research
  14. Chris Ponting
    Post

    Autoimmunity-Related Risk Variants in PTPN22 and CTLA4 Are Associated With ME/CFS With Infectious Onset (2020) Scheibenbogen et al.

    An infectious onset is not reported for this UK Biobank cohort. Nevertheless, I would expect these SNPs to skew towards zero. But they do not....
    Post by: Chris Ponting, Apr 12, 2020 in forum: ME/CFS research
  15. Chris Ponting
    Post

    Autoimmunity-Related Risk Variants in PTPN22 and CTLA4 Are Associated With ME/CFS With Infectious Onset (2020) Scheibenbogen et al.

    Can these SNPs be replicated? The answer is "no". I went back to the UK Biobank CFS findings (far more than 305 ME/CFS patients) and asked what is...
    Post by: Chris Ponting, Apr 12, 2020 in forum: ME/CFS research
  16. Chris Ponting
    Post

    Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Fluge, Mella et al 2020

    comment copied from Genome-wide association study thread Small study, but great to see a genetic signal. This needs replication and more samples,...
    Post by: Chris Ponting, Mar 27, 2020 in forum: ME/CFS research
  17. Chris Ponting
    Post

    Current: Genome-wide association study in (CFS/ME) to uncover the genetic susceptibility and identify biological pathways involved

    Small study, but great to see a genetic signal. This needs replication and more samples, but at the moment this does point towards an adaptive...
    Post by: Chris Ponting, Mar 27, 2020 in forum: ME/CFS research
  18. Chris Ponting
    Post

    Edinburgh Chris Ponting GWAS PhD project advert

    Yes, this is true. I am hoping (not expecting!) that the GWAS is funded and that a funded PhD student picks the study. If the GWAS is not funded...
    Post by: Chris Ponting, Jan 19, 2020 in forum: ME/CFS research news
  19. Chris Ponting
    Post

    UK Genome Wide Association Study (GWAS) project - draft website goes live, feedback sought on recruitment plan, and updates

    Thanks. What other optional questionnaires would you like to see? SF-36, for example? Yes, we need to ensure that the questionnaire load for a...
    Post by: Chris Ponting, Jan 2, 2020 in forum: ME/CFS research news
  20. Chris Ponting
    Post

    UK Genome Wide Association Study (GWAS) project - draft website goes live, feedback sought on recruitment plan, and updates

    If there is a compelling argument for such a trial (passed by an ethics committee) then eventually yes, but more likely (and sooner) we expect...
    Post by: Chris Ponting, Jan 1, 2020 in forum: ME/CFS research news
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