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  1. sebaaa

    Is “inability to recover and improve from exercise” a core component of ME/CFS? How common is it?

    In the title and poll, I'm not referring to ME/CFS or PEM improving from exercise. Clearly, it doesn't happen. I'm referring to muscle improving, as in a localized effect. I guess I should've been more specific with the definitions. By "exercise," I mean activity that increases capacity to...
  2. sebaaa

    Is “inability to recover and improve from exercise” a core component of ME/CFS? How common is it?

    I know this is similar to another thread by @rvallee but I think the poll warrants its own thread. I don't think I can properly recover from exercise. I feel like I never improve. It doesn’t matter if it’s swimming, running or pushups and pullups. I feel the lactic acid, and I always seem to...
  3. sebaaa

    Call for submissions for special issue, "Biomarkers in Chronic Fatigue Syndrome (ME/CFS)", Biomolecules journal, deadline 30th June 2021

    I wonder if this means that his "novel diagnostic platform" didn't pan out as well so he's trying to take the attention to something else... I hope not.
  4. sebaaa

    Fatigatio digital symposium in Hannover, 19 September 2020

    Yes, I watched the whole thing. Prusty essentially narrowed down the "something in the blood," which causes excess mitochondrial fragmentation in healthy cells, to 3 different molecules: autoantibodies (e.g. IgG), anti-C1q antibodies, and exosomes containing viral mRNA and proteins. He also...
  5. sebaaa

    Tell Your Representative to SUPPORT INCREASED FUNDING FOR POST-VIRAL-DISEASE RESEARCH INTO ME/CFS!

    The amount of co-sponsors is now at 20, including a republican, which is good. I asked OMF and MEAction if they could maybe support this more e.g. by telling everyone in their email list to support HR 7057. I emailed local ME/CFS organizations to ask if they could tell their members to support...
  6. sebaaa

    Members of the European Parliament call for more funds for research into ME/CFS

    I'm glad to hear that this went well! So how do you make it an obligation? Should a petition call for specific actions like funding equal to 1% of the disease burden by e.g. October 2020? Or maybe something with Horizon 2020? I mean when 676 MEPs explicitly agree that there needs to be more...
  7. sebaaa

    Will any antibiotic do for SIBO or just Rifaximin?

    I think broad-spectrum antibiotics work but Rifaximin is preferred because of less side effects. Also, I think SIBO might come back if you don't fix your diet. https://www.siboinfo.com/antibiotics.html is a good source for SIBO
  8. sebaaa

    Short summary of meds i tried by now

    Have you by any chance tried Valcyte, or other antivirals? It seems like a common drug that many patients try.
  9. sebaaa

    Low-dose Naltrexone articles and experiences

    I was just taking it a while ago but I stopped because it didn't help at all. I took it for about 10 weeks, slowly working up from 1.5mg to 5mg. I used this website to figure out the duration. On that website Jarred Younger states that "it can take 8-10 weeks to determine if you will respond to...
  10. sebaaa

    USA: Rep. Jamie Raskin introduces legislation to address potential rise in ME/CFS from COVID-19 pandemic

    That's great! I hope it passes and that something similar will happen in the EU. If I read this correctly, I think it will allow "$15,00,000 [in funding] for each of fiscal years 2020 through 2024." I'm guessing the lack of a zero is a typo.
  11. sebaaa

    Gene Therapy to Eradicate Herpesviruses

    This is something that I wrote so that I can have a good overview on CRISPR/Cas9 and to also layout my thoughts in a logical manner since it’s often difficult to think with my severe brain fog. I hope that someone can find use for this and maybe suggest improvements if necessary. I think there...
  12. sebaaa

    Research news from Bhupesh Prusty

    "Trying to conceptualize an RNA-based therapy." RNA-based therapy includes RNAi, and antisense therapy which are both used to silence specific mRNAs. I'm wondering if this suggests that the "something in the blood" is an mRNA or a group of mRNAs specific to HHV-6 or other viruses. Or perhaps...
  13. sebaaa

    European ME Coalition (EMEC)

    I haven't used the free version of Wordpress so I'm not exactly sure how it works but if you have access to the hosting panel or .htaccess you should be able to change it. I can help with that if you want. Though, it might just be that you can't change it since you don't own the domain.
  14. sebaaa

    European ME Coalition (EMEC)

    Good on you guys for fighting the good fight! I was testing your site and I noticed that the links on the home page at the bottom that go to your Wordpress site don't work. Maybe you guys are already aware of this. Also, I think you guys should auto-redirect the Wordpress domain to your new...
  15. sebaaa

    Etiology: graphic representations

    Here's a review article from 2019 by Warren Tate that should give you an overview of the current scientific literature. It doesn't have a diagram so I guess you could make your own and add bits from this review article to it. Of course, it's a bit difficult to have anything conclusive since...
  16. sebaaa

    A nanoelectronics-blood-based diagnostic biomarker for ME/CFS (2019) Esfandyarpour, Davis et al

    If you look at Photo (B) in Figure 2 it seems like it has a large amount of sensors. I'm not sure if it's hundreds or thousands of sensors. Also, on the same page it says that "the gold microelectrode biosensors in each well of ACEA’s electronic microtiter plates (E-Plates®) cover 70-80% of the...
  17. sebaaa

    A nanoelectronics-blood-based diagnostic biomarker for ME/CFS (2019) Esfandyarpour, Davis et al

    Merged thread Difference Between the Nanoneedle and Other Impedance Analyzers? What’s the difference between the nanoneedle and off-the-shelf impedance analyzers? Can off-the-shelf counterparts separate ME/CFS PBMCs with ME/CFS plasma from those with healthy plasma? And while utilizing the...
  18. sebaaa

    Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in ME/CFS - 2020 - Schreiner

    That's a really good point! I was thinking that you could avoid the issue of needing the nanoneedle to find the "something in the blood" by replicating Fluge & Mella's study where "cultured human muscle cells indicated that exposure to ME/CFS serum led to increased rates of mitochondrial...
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