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“Dietary sodium may stimulate vasopressin secretion through extracellular osmolality or even by a direct effect of extracellular sodium on periventricular receptors.“...

Could it be helpful to take some salt first thing in the morning? https://www.sciencedirect.com/science/article/pii/S2211124721001807 Highlights • High dietary salt increases the osmoresponsiveness of vasopressin neurons in vivo • Salt loading and AngII-salt both increase the mEPSC...

Glutamate also increases cerebral blood flow which might be a compensatory mechanism that when working can keep a pwME in the more mild categories.

Could this be a clue as to why benzodiazepines seem to increase capacity/functionality acutely? This is anecdotal of course but it seems to at least be true for other patients as well. “Thus, in vivo low concentrations of benzodiazepines may reduce synaptic glutamate concentrations by...

Quick search of the literature found that this gene is HIF-1a and hypoxia activated in cancer cells

Unfortunately Mestinon never helped me all that much in the past. Maybe it’s worth another shot though

https://pubmed.ncbi.nlm.nih.gov/27973551/ Rapamycin dephosphorylates ATG13 on paper but didn’t help me

From one paper I read in a quick Google search mTorC1 is directly upstream of p-ATG13

Just wanted to add that I tried Rapamycin for a few months a couple years ago and even though it never helped I stuck with it because some of us here were very hopeful. However it looks like mTor and ATG13 can become uncoupled so perhaps inhibiting mTor might not have been enough to stimulate...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714170/ ATG13 has non-autophagic capabilities and it appears to be anti-viral and relate to interferon release

@SNT Gatchaman They say it’s unexpected but I have seen eNOS come up at least once in the ME literature. This is a novel mechanism though. I’m interested to see how this gels with some of the leading endothelial dysfunction theories.

@mariovitali

@JES I had almost the exact same reaction to NatTokinase/Bromelain. A hopeful start but definitely worse after a few days. The flu like symptoms went away as soon as I ceased the regimen. Do you have any speculation on what may be the reason for this worsening caused by fibrinolytic enzymes?

New to me was the findings of high phenylalanine and low BH4. Ron also said they have other indications of low dopamine. Going to add Vitamin C/Folate to my supplement regimen to try and raise BH4

Are you hinting at a compound you know of? I’d be quite interested in taking a look at such a thing.

This is extremely interesting to me as hot baths and heating pads, along with ice alternatively, seem to allow my body to accept some help energy wise heating the body and moving the blood etc. Some days it works better than others, but it does seem that treatments that lend energy to the body...