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  1. John Mac

    Article: From Long Flu to Long COVID: A Brief History of Postviral Illness, 2025, Mendenhall, Finkelstein

    It amazes me that people believe that Covid, which killed over 7 million people worldwide, can kill you but if it doesn't then it can only leave you 100% healthy i.e. that Long Covid doesn't exist.
  2. John Mac

    Trial Report Beneficial effects of intermittent intravenous saline infusion in dysautonomic patients with [ME/CFS]: a case series, 2025, Sjogren et al

    Now published: https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1601599/full
  3. John Mac

    Trial Report Fatigue, Interoplastic and Nociplastic Distress in ME/CFS, Gulf War Illness and Chronic Idiopathic Fatigue, 2025, Baraniuk et al

    Full title: Fatigue, Interoplastic and Nociplastic Distress in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome, Gulf War Illness and Chronic Idiopathic Fatigue https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2025.1530652/abstract Myalgic Encephalomyelitis /...
  4. John Mac

    Closed 2022 Pilot study in Norway - Daratumumab in ME/CFS

    Now published Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) entails low quality of life for patients and massive societal costs. There is an urgent need for elucidation of disease mechanisms and for rational treatment. Our working hypothesis is that ME/CFS in a...
  5. John Mac

    Trial Report Distinct white matter alteration patterns in post-infectious and gradual onset chronic fatigue syndrome revealed by diffusion MRI, 2025, Yu et al

    Abstract While post-infectious (PI-ME/CFS) and gradual onset (GO-ME/CFS) myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) manifest similar symptoms, it has long been suspected that different disease processes underlie them. However, the lack of biological evidence has left this...
  6. John Mac

    UK: Disability benefits (UC, ESA and PIP) - news and updates 2024 and 2025

    They are being referred to as "Blue Labour". Very little difference between the two main parties.
  7. John Mac

    Review Redefining Mitochondrial Therapy for ME/CFS: The Case for MOTS-c, 2025, Klimas et al

    https://www.preprints.org/manuscript/202507.0058/v1 Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating, multi-system disease characterized by profound fatigue, post-exertional malaise (PEM), and a constellation of immune, neurological, and autonomic symptoms...
  8. John Mac

    Immune Signatures in Post-Acute Sequelae of PASC and ME/CFS: Insights from the Fecal Microbiome and Serum Cytokine Profiles, 2025, Tobi et al

    Full title: Immune Signatures in Post-Acute Sequelae of COVID-19 (PASC) and Myalgia/Chronic Fatigue Syndrome (ME/CFS): Insights from the Fecal Microbiome and Serum Cytokine Profiles Abstract While there are many postulates for the etiology of post-viral chronic fatigue and other...
  9. John Mac

    Preprint There Is No Established Connection Between Long-COVID and Chronic Fatigue Syndrome, 2025, Kouyoumdjian et al

    https://www.preprints.org/manuscript/202506.2016/v1 Abstract Fatigue is the most common symptom of Long-COVID (LC), characterized by persistent or new symptoms occurring at least three months after the initial SARS-CoV-2 infection, with no other identifiable cause. This study aims to assess the...
  10. John Mac

    Open Norway: Plasma cell aimed treatment with daratumumab in ME/CFS - Haukeland University Hospital

    Pilot Study published https://www.s4me.info/threads/plasma-cell-targeting-with-the-anti-cd38-antibody-daratumumab-in-me-cfs-a-clinical-pilot-study-2025-fluge-et-al.44736/#post-618982
  11. John Mac

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    Thread on the proposed full trial https://www.s4me.info/threads/norway-plasma-cell-aimed-treatment-with-daratumumab-in-me-cfs-haukeland-university-hospital.44450/
  12. John Mac

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1607353/abstract Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) entails low quality of life for patients and massive societal costs. There is an urgent need for elucidation of disease mechanisms...
  13. John Mac

    Replicated blood-based biomarkers for Myalgic Encephalomyelitis not explicable by inactivity, 2024, Beentjes, Ponting et al

    https://www.bbc.co.uk/news/articles/cy8k73443g4o Chronic fatigue is not in your head, it's in your blood - experts People with ME - or chronic fatigue syndrome - have major differences in their blood compared with healthy individuals, experts have found. University of Edinburgh researchers...
  14. John Mac

    UK: Disability benefits (UC, ESA and PIP) - news and updates 2024 and 2025

    https://www.gov.uk/government/statistics/esa-outcomes-of-work-capability-assessments-including-mandatory-reconsiderations-and-appeals-june-2025/esa-work-capability-assessments-mandatory-reconsiderations-and-appeals-june-2025
  15. John Mac

    Preprint Hypothesis: A Mechanical Basis: Brainstem Dysfunction as a Potential Etiology of ME/CFS and Long COVID, 2025, Jeff Wood, Kaufman et al.

    Abstract The underlying pathologies driving post-acute infectious syndromes (e.g. myalgic encephalomyelitis / chronic fatigue syndrome, long COVID, etc) remain poorly understood. Given the extreme burden these illnesses impose on suffers, and the dramatic increase in cases following the COVID-19...
  16. John Mac

    [Poster] Changes in blood metabolic profile during repeated cardiopulmonary exercise testing (2xCPET) in ME/CFS patients, 2025, Chapola

    Henrique Chapola, Sissel Elisabeth Furesund Dyrstad, Karl Johan Tronstad are co-authors in this recent thread https://www.s4me.info/threads/charting-the-circulating-proteome-in-me-cfs-cross-system-profiling-and-mechanistic-insights-2025-hoel-fluge-mella.44410/#post-613425
  17. John Mac

    BBC News: First bacteria we ever meet can keep us out of hospital

    https://www.bbc.co.uk/news/articles/cgr5lej9l8lo The first bacteria our bodies meet – in the hours after we're born – could protect us from dangerous infections, UK scientists say. They have shown, for the first time, that good bacteria seem to halve the risk of young children being admitted...
  18. John Mac

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    This is the same for me also. I think this is very common in people with ME. When I first got ill and was still working and was trying to explain my symptons of fatigue to disbelieving people, "so what, we all get tired!", it was only when I mentioned that I felt exhausted in the morning and...
  19. John Mac

    Review Evaluating Pacing Therapy versus GET for improving fatigue, pain, and quality of life in adults with ME/CFS, 2025, Cooper

    Full title: Evaluating Pacing Therapy (PT) versus Graded Exercise Therapy (GET) for improving fatigue, pain, and quality of life in adults with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Systematic Review...
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