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Did you look into this further? Just curious as it also seems to be a (low potency) CD38 inhibitor in vitro.

I can't help but wonder if it's possible they are interpreting the results backwards? I haven't read the paper, but this quote seems to me as if they're suggesting that the increase in AMPAR is at fault and thus artificially blocking it would/could restore cognitive function. But what if the...

Merged thread ---------------------- Here's a patent application talking about using a medication similar to Modafinil, Lauflumide (aka Flmodafinil), for Long COVID and ME/CFS. The US version has been published this year, so it looks like they are actively seeking approval. Their background...

Can anybody point me to the study protocol?

I definitely had more PEM days on which I felt more exhausted and with my classic sore throat I get. That's for sure. But on those days I don't go to work. So far, I don't think that modafinil has caused PEM for me, but I'll stay vigilant. I've seen and heard of Modafinil being used off label...

Thank you all for the insightful replies! If it makes any difference, I'm a male in my late 20s and considered "gifted" (don't like that word) - so likely also not traditionally neurotypical. I see myself in some of your anecdotes, but also not at all in some. Funny how everybody perceives...

What if the acquired disease makes it more difficult to mask/deal with ADHD-like symptoms that have been around forever (but mainly managed by oneself)? I guess this is my point - if I even have one.

Thank you all for the answers so far! Thanks, this sounds quite similar to what I (think I) am experiencing. I'm "only" properly sick with PEM for 2 years, though. I feel like most of the answers I've given to the ASRS (down below) have been struggles my whole life, but now are much more...

Original title: Distinguish ADHD symptoms from ME/CFS symptoms? ------------------------------------------------------------------------------------------ Hey! As of recent, I've entertained the idea that I might have undiagnosed ADHD. Mainly the attention deficit part rather than the...

No idea, sorry. As they already use it in the clinic, I would assume they're going for a proper RCT.

Charité is planning a trial with aripiprazole, according to their Gantt chart presented at the Fatigatio conference. Start in early 2026, seems to be called ARISE.

Not much more info than that. But mentioned here.

Merged post ---------------- At around 2:46:30, Carmen Scheibenbogen mentions they have private funding for an anti-CD38 study, and also interest from Sanofi to collaborate. They seem to call it AIM-ME. Does anybody know more about this?

Thanks! I was thinking of this one with a similar result. https://pubmed.ncbi.nlm.nih.gov/38258677/

I'm not sure I remember correctly, but is that the one where they used 6 mg? I recall Carmen Scheibenbogen suggesting this being a dose that's too high. Convenient excuse, but I believe this single study with a single dose might not show us the whole picture. Suppose the lift trial could maybe...

I for my sake can say - as I have in the Mestinon thread - that mestinon has greatly improved my quality of life (compared to other medication used in POTS like beta blockers, fludrocortisone, midodrine). Unblinded of course, but hard data such as step counts and heart rate corroborates my...

As mentioned in other threads - medication that actually improves deep sleep, such as gabapentinoids and baclofen help me immensely for sleep. Personally used as needed, e.g. when having PEM. Other medication used for sleep without increasing deep sleep, such as H1 antagonists/inverse agonists...

What about in MOGAD? Not produced in the CNS, but anti-MOG nonetheless.

Of available compounds, maybe high enough doses (however much that may be) of apigenin as a known (low potency IC50 ~ 10 uM ) CD38 inhibitor?

Interesting read.