I've often wondered about something very similar - that the delayed 24hr + PEM we see in the condition is due to some regulatory processes (like the cellular housekeeping you mentioned) that go on in sleep being impaired in patients with ME/CFS. I have no biomedical training so I have no idea if...
There's also the possibility of patients with psychosis having fatigue from an additional health problem but it being put down to their mental health condition and not investigated through the sheer diagnostic laziness of their doctors.
Inside health on Radio 4 had an episode on Long Covid yesterday. I didn't catch all of it but the bit I did listen to involved a patient of the Leeds Long Covid service describing 'pacing' as including 10% increases in activity.:banghead:
Also it seems that they haven't been having much success...
It could be but I think it's unlikely seen as I checked today and she still isn't listed on the staff profiles for the department on KCL website. You are right though it's probably not a good idea to jump to conclusions on this I'll edit my previous post.
I thought read through this whole thread today but it looks like @Jonathan Edwards had already pointed out that:
So the researchgate profile conflicts with the information previously found on the KCL staff list and what the KCL website states today.
Edit: Conclusion of this post is now more...
Forgot to mention that on the systematic review it states that Aston and De Rijk work at KCL If they don't it could be considered research fraud. There's an article on false affiliations in research from Elizabeth Bik here.
Edit: Punctuation and Clarity
So I found a profile for Jacqueline Aston on researchgate.net that states she works in the department of Psychosis Studies at King College London but only lists three research papers on the Lightning process on her profile. The photo provided looks to be the same woman from the Lightning...
The thing that really gets me is that NICE has been using the GRADE system since 2009. If as they argue it unfairly downgrades the evidence base of rehabilitative treatments then why did they not raise the issue earlier before over a decades worth of NICE reviews were produced using 'poor' methods?
I did a quick Google of the use of the term "secondary gains" in relation to illness. It appears to be a term taken from psychoanalysis (Freudian or otherwise) and usually referred to the "gains" a conversion disorder patient experiences from being ill.
I feel like by now I should no longer be...
To add insult to injury it looks like the theme of this special issue the article is to appear in is 'psychosomatics'. (I'm trying to double check that this is the case and have asked them directly via twitter)
He's not just tweeting about Richard Horton; It seems Sharpe got up this morning and decided that being patronising to random people using the #PACEtrial hashtag was a productive use of his day:
I would say it's unbelievable but sadly this kind of thing doesn't surprise me any more. Funny how "activist" becomes a good thing to be when it's applied to him. :banghead:
The website doesn't inspire any confidence in the course (but the new age drivel is quite entertaining). Here are some extracts for anyone that doesn't want to waste time on the website:
He even mentions Psychoneuroimmunology:
(I think stand is a typo for and)
Also the website looks like...
CBTmasons? They have the all the cultish, secret handshake, favour for a favour cronyism of the masonic lodges- all they are missing are the funny aprons.
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