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The concept that ME/CFS pathology might originate in bone marrow aligns well with immune dysregulation patterns. When the marrow produces an unbalanced mix of immune cells, these cells can interact abnormally in lymph nodes and spleen, reinforcing chronic inflammation. Since bone marrow...

It’s a shame that even when journals ask for data, most authors still don’t share it. Maybe journals should make it mandatory to upload data online or actually check that it’s there.

You might check out HealthUnlocked’s autoimmune community or PatientsLikeMe, both have lots of friendly people asking newbie questions.

From what I’ve tried, low-dose gabapentin (around 300 mg) before bed really helped smooth out my sleep, fewer wakes overnight and more deep sleep, so mornings feel way less brutal. I haven’t tried clonidine or baclofen yet, but they might be worth a shot if you can get them.

I have a question concerning my personal sleep. How concerned should I be that at least 1 night a week I look at the ceiling and cannot fall asleep for the life of me, last time I check my clock it shows 3, almost 4 AM then I fall asleep unexpectedly. I need to wake up before 7AM, and this...