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I challenge the assumption the muscle acidosis is lactate. Many ME/CFS patients exhibit low pyruvate and low to normal lactate. My metabolite tests revealed undetectable pyruvate and low/normal lactate. My peripheral blood gases tests however show acute respiratory acidosis. Perhaps the acidosis...

Yes, I’m sure you are most likely correct, butyrate without sodium is a known HDAC inhibitor. So in the context of this study, it’s probable the butyrate has dissociated from its original form. It could simply be that too much butyrate is overly suppressive…no doubt they substantially overdosed...

I think this could confuse the issue between the benefits of butyrate v sodium butyrate. Sodium butyrate is a stable form of butyrate that is commonly used in supplements, but I’m not aware there is any evidence that production of butyrate by the microbiome is in this sodium form? Butyrate...

I agree, this I believe is common in more moderate to severe patients. I am one, and from early in the disease onset I had a progressive worsening of this experience with just short walks. I wouldn't describe it as cramping, but more like the limb becoming more stiff or 'rigid', you...

In StatNews: https://www.statnews.com/2025/04/23/lyme-disease-clues-to-chronic-form-treatment-antibiotics/

In the months following ME/CFS onset, I developed a pain at the junction between the sternum and rib, not a constant ache but pain when pressed specifically at the junctions, and with a deep breath if I recall correctly (10 years ago). The practitioner at the time described it as...

Wow! This seems significant to me, exhibiting the effects of patient serum on muscle tissue just in a matter of days. Thanks for posting @Dolphin There is suggestion of the PDK4-SEPT2-DRP1 axis implicated in neurodegenerative diseases and ER stress, but in context with above study in muscle...

Here is the metabolic pathway for the production of 2HB: a byproduct of (excess) 2ketobutyrate (2KB) mediated by lactate dehydrogenase (LDH), the enzymes activity enhanced with high NADH/NAD+ ratio. [Courtesy of the following link: Which Role Plays 2-Hydroxybutyric Acid on Insulin Resistance...

Thanks for posting @Andy. This possibly deserves some discussion as to what goes wrong between what is a normal muscle recovery post exercise and what is metabolic abnormality, particularly seeing it is also identified pre ME/CFS onset. Elevated 2-Hydroxybutyrate (2HB) is usually a sign of...

I think this gets back to the whole point of this thread and power output is a critical measure of that. When we think back to our healthy selves, I recall that explosive power of launching myself out of bed or even up a flight of stairs. I've completely lost all that, even to the depths of...