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I no longer have access to mapMECFS, the platform for sharing raw data for the deep phenotyping study. But I previously posted about doing statistical tests on all 435 CSF metabolites, and cortisol was in fact one of the chemicals that was in the data. And in another post where I posted the...

Good catch. They've published a correction. Corrigendum to “Beyond COVID-19 in people with HIV: Specific miRNA expression profile persist after SARS-CoV-2 clearance” [J Infect Public Health 19 (3) (2026) 103108] Web | PDF

I'm not sure if this is what you mean, but I was initially also thinking that it was basically outputting the same things you'd find in GTEx. But I don't think it's that. I'm pretty sure it doesn't "know" where in the genome the strand of nucleotides you give it is, or where any genes are. I...

Africa Africa (excluding South Africa and MENA countries) South Africa Asia China India Israel Japan Korea Middle East, North Africa (the MENA countries) and Turkey Russia South Asia South-East Asia Australia Aotearoa/New Zealand and the Pacific Islands Australia Europe Austria and...

The plot for cortisol levels in cerebrospinal fluid looks similarly striking to the CRH finding. I would think that this would have already been tested in people who are alive, though I can't immediately find a study looking at CSF cortisol in ME/CFS. I don't see any mentions of CSF on the...

Interestingly, the top four significantly enriched tissues based on MAGMA are the same four tissues as DecodeME, in the same order: Frontal Cortex, Cortex, Anterior Cingulate Cortex BA24, Nucleus Accumbens. From DecodeMe: Edit: Looking at the MAGMA plots I previously compiled from several...

Large sample size is very important in GWAS, and that was their rationale for combining. Even though they're not the same disorders, I think it's reasonable to suspect that they may have some factors in common, which a shared GWAS would uncover. Another benefit is that any such findings would...

NEGR1 was almost significant in DecodeME, and has had significant associations in depression GWASs. It's mentioned here for anxiety:

Both technically right, but just to prevent confusion, the position given by jnmaciuch and in the anxiety paper, is using GRCh37 assembly coordinates, while the one I gave is in GRCh38 coordinates, which is the assembly used by the DecodeME summary stats and LocusZoom above. (Though it's close...

The BTN2A2 SNP is given as rs58825580, which is chr6:26365451:T:G. In DecodeME, that SNP had a -log10p=1.60642, or p=0.025.

Thread for 2026: Walk for ME 2026

Note that this paper is available to read on PubMed Central (PDF).

Symptom Clusters in ME/CFS Reflect Distinct Neuroimmune and Autonomic Pathophysiological Mechanisms: A Translational Model Habermann-Horstmeier, Lotte; Horstmeier, Lukas Maximilian [Line breaks added] Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating...

The gene expression predictions were the only ones I tested so far (because that's the only ones I really understand what they are), but there are several other prediction types that might be useful. Maybe while the top variant in DecodeME predicts changes in expression in lots of genes, there...

There's a lot more for me to read about it to understand, but it's basically a machine learning model trained with lots of genetic and other data to look at a string of DNA (up to 1 million base pairs) and predict various things like how much RNA will be expressed all along the strand you gave...

Hmm, yeah, the caption says each point is an image, but the number of points seem to add up to the number of individuals, so maybe they labeled it wrong?

I think >= 10 images of cells per person, if I'm understanding this right: I don't have the energy right now to read this and try to figure out what exactly they mean by images/replicates etc. But I'd agree that if the right panel of 1B is based on a Mann-Whitney of many points per individual...

See this thread for discussion about Walk for ME from years 2023-2025: UK: Walk for ME

Here's the information sheet with more info, linked from the restandmecfs.com website: https://drive.proton.me/urls/RE5AGP2W3W#ghfXfevCCoou

In this post? https://www.s4me.info/threads/plasma-cell-targeting-with-the-anti-cd38-antibody-daratumumab-in-me-cfs-a-clinical-pilot-study-2025-fluge-et-al.44736/post-672520 That table is showing baseline steps. I see Table 2 in the study has step count at 17–21 mo, but on a skim, I don't see a...