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I haven't posted for a long time because I now visit this site only occasionally. This is because I have had such a marked improvement, which I attribute to adopting a ketogenic diet with time restricted eating, that I am too occupied with other things. It is only a partial remission though and...

I've experienced the same thing. It's not only genetics that can interfere with the conversion.

I agree. As I've already said, while we can make MK-4, we don't appear to make enough. We need exogenous MK-4 and MK-7.

Humans do make MK-4 using the relatively newly described enzyme UBIAD1. Here is the Uniprot entry for the human enzyme. It is widely expressed in human tissues - see here. .

This would certainly help but may not be sufficient. Brightly coloured vegetables of all kinds are rich in beta carotene. Efficiency at conversion to vit A varies with individuals so this may or may not be adequate. Green leafy vegetables are good sources of vit K1, magnesium and calcium...

Vit A and D bind to and activate nuclear receptors that in turn act as transcription factors - ie they bind to and regulate the expression of a number of different genes whose products cause the effects we attribute to the vitamins. There are two types of nuclear receptors activated by vitamin...

Here is a very thorough analysis of the many defects of this particular study and of the limitations of nutritional epidemiological studies in general. Here is another consideration of the general problem of these types of studies.

Their own disclaimers. And as already noted, dietary assessment was by self-reported questionnaire - a notoriously unreliable method. So yet another poorly designed nutritional study whose conclusions can't be relied on because of many possible confounders. Why do they keep doing them and...

Sorry wrong spelling - look for cronometer

Use chronometer on your computer. You can enter any food or group of foods and it will give you a breakdown of the macro nutrients (as well as many micro nutrients if you are interested).

Just to warn people, if your glucose management/insulin sensitivity if faulty for whatever reason, you may have trouble achieving ketosis initially and may see paradoxical blood glucose rises. As I noted in an earlier post, I have been eating lowish carb for years and for the past few months...

Thanks for posting this. You have inspired me to try a ketogenic diet again. I did give it a go several years ago and just couldn't stick to it. More recently I am finding less and less carbohydrate seems to suit me and currently am eating no more than 50 g/day. I am hoping this will reverse a...

I had to refresh my memory about what the 3 sets of numbers mean - ie as used by Shoemaker. You can see more about that here and here. So the first number is DRB1, the second is DQB1 (Shoemaker doesn't specify DQA1 or DQB1 but if you look on the LabCorp test shown in the second link you can see...

I suspect that your doctor is referring to the common COMT variant rs4680 AKA V158M. Approximately 50% of the population is +/- for this variant and 15-20% is +/+. The variant does slow the function of the enzyme, whose normal role is the breakdown of dopamine and related neurotransmitters...

uBiome turn-around can often be 2-3 weeks - certainly quicker than that.

Unfortunately there is no single ideal test for checking gut health. I agree that hydrogen and methane breath tests can be useful for detecting SIBO, though be aware that there is disputation about what means what. This however is concerned only with the small intestine, not the colon where...

This varies greatly - it depends on the gene. In the case of GSTM1, the deletion mutant is very common, the frequency ranging from about 0.3 to 0.5. GSTM1 is one of 7 versions of cytoplasmic GST, so other isotypes can step in if the M1 type is absent. There has been some suggestion that the...

Everyone has them to a greater or lesser extent. This implies

I've just caught up with this thread and read the article on Andrew Lloyd. I found it to be excellent - thanks @dave30th. I barely noticed the commentary in the paragraph that @Bill took such exception to. I certainly read it as fair comment. What on earth was all the fuss about? Do people...

He says specifically that he is looking for whole genome or exome sequences, not 23andme.