Search results

Both studies used Fukuda. So basically this has never really been tested in ME/CFS.

I could only find two studies that monitored sleep quality after an exercise test. The other one is: Sleep is not disrupted by exercise in patients with chronic fatigue syndrome, 2010, Togo et al (thread) Most of the authors are the same, including Benjamin Natelson. Still haven't read these...

Sleep is not disrupted by exercise in patients with chronic fatigue syndrome Fumiharu Togo, Benjamin H Natelson, Neil S Cherniack, Marc Klapholz, David M Rapoport, Dane B Cook Published: 2010 Purpose Patients with CFS report that exertion produces dramatic symptom worsening. We hypothesized...

The effects of exercise on dynamic sleep morphology in healthy controls and patients with chronic fatigue syndrome Akifumi Kishi, Fumiharu Togo, Dane B Cook, Marc Klapholz, Yoshiharu Yamamoto, David M Rapoport, Benjamin H Natelson Published: 2013 (Line breaks added) Abstract Effects of...

I didn't know if it was worth mentioning, but I've wondered if cognitive PEM might just be prolonged use of eye muscles. At least for me, most cognitive crashes come from activities involving long focus on a page or screen. I also have felt like I overexert even just from focusing on an...

Lately, I've been thinking more that it's related to sleep in ME/CFS as well. It seems so strange that exertion causes insomnia. I think this is common in ME/CFS but I'm not sure. Just a couple days ago, after spending hours intensely focusing, I couldn't fall asleep until around 4 AM and...

That's interesting to think about. Why would one feel drained if not a lack of energy available for the brain? Why can't a healthy person read for 14 hours a day without feeling mentally exhausted? (Actually, do they? Maybe it's a different feeling.) Is it a damage thing, like using the brain...

I'm not able to edit this anymore, so adding a reply. I was looking through these SNPs, and it seems like they labeled rs7317941 incorrectly as INSR in Supplementary Table 4. dbSNP says it is part of GPC5.

Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies novel methylation loci, 2019, Smith et al (Preprint) Using the Coriell Personalized Medicine Collaborative Data to conduct a genome-wide association study of sleep duration, 2015, Scheinfeldt et al...

Not sure if this is the right third study, but it's another genetic study: Genetic Risk Factors for Severe and Fatigue Dominant Long COVID and Commonalities with ME/CFS Identified by Combinatorial Analysis, 2023, Taylor et al Quickly looking at the three studies, it looks like ATP9A was...

There's a disease signature? I'm intrigued. The rest of the paper looks really interesting, but for now I've only looked at the part about this. It seems to say a gene was significant in three studies. The following two, and I'm not sure what the third one is because the citation number is...

The results and statistics have been added to ClinicalTrials.gov. Out of around 10 different outcomes with stats, only one is below p of 0.05, and it was added post-hoc: "Change From Baseline to Week 6 and Week 13 in Distance Traveled During 6-minute Walk Test (6MWT) - Subjects Walking ≥205...

CNN: Trump administration directs federal health agencies to pause communications Link

Is the report like a personalized letter for each child explaining the results? Or is it a standard fill in the blank format like: "Sue scored a 4 for the fatigue scale. This scale represents ..." If the latter, maybe if you're able to, you could share the format that parents will be getting?

"Open Medicine Foundation (OMF) is proud to announce the addition of two distinguished experts to our esteemed Scientific Advisory Board (SAB): Dr. Michelle James and Dr. David Kaufman." Read more here

Jonathan made a good point in another thread: Any association involving HLA might just be related to how the body deals with an infection. We already know that more severe infection increases the risk of long COVID - maybe ME/CFS too - so what we see in HLA in long COVID or ME/CFS might just...

Isn't it possible the toxin migrates to somewhere like the brain and maybe it takes time to eat away at the myelin or something? (Maybe something more difficult to test for) Can you explain this part? I'm not really sure what you're saying.

Yeah, but that's basically what most pilot studies are, and they're followed up by a larger study with more power. I understand the method they used here and it makes sense to me for testing their hypothesis. (Notwithstanding any issues with the hypothesis itself that Jonathan mentioned.) In...

I don't think this is a tiny sample size. I think genetics studies generally need enormous samples when they are testing massive numbers of genes or the whole genome, to have enough power to detect effects after multiple test correction, and they have to correct for thousands or millions of...

Yeah the first study could easily be biased. So I'm mainly intrigued because I think we had seen a couple studies already finding associations between HLA and long COVID. Though my memory is foggy, I'll have to look. I'm not thinking too much about whether NetMHCpan shows what is says it...