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Basically no difference in the time taken to return to baseline number of steps after Covid-19 infection (Edit - !! - i.e. absolutely no evidence for those diagrams of the Vicious Cycle, or reduced effort preferences.) See Table 1 From Table 1: Of the 279 people with Long Covid, only 33 (11.8%)...

Thanks Mij. Change in resting heart rate Change in steps (red=LC; blue = recovered) Change in sleep It's a shame that the definition of Long Covid is so loose. I haven't yet read the whole study to see if there might be other problems. Maybe there are seasonal impacts on activity levels...

This seems worth talking about a bit. ANZMES could choose to be an Incorporated Society, in which case it would continue to be accountable to its members and officers would be elected. It has however chosen to be a Charitable Trust Board. The Trustees choose themselves, and later choose...

RESULTS Part B Convalescent samples: NeuroPASC samples: I'm not sure that we should be too excited by these results. The sample size at 20 in each group is small. Not a single MDP or cytokine was significantly different between the two groups (see Table 2). So, they have turned to...

A correlation between physical activity and a molecule doesn't prove much. As you say, the levels of the molecule might be an indication of disease, and the disease might be causing inactivity. But, if the 'ME/CFS' group and the healthy group both have the same relationship between levels of...

I agree with most of this. The paper does need reworking. As you say, we need graphs of actual values (with separate charts for male/female, and adjustments for age if appropriate). I don't have a background in advanced statistics, so I say the following with much hesitation and willingness to...

It is a question we wrestle with in the moderation team. I don't think it's just a question of being tidier. If someone wants to think about biomarkers and diagnostic tests, it seems sensible to direct them to a thread where other useful points may have been made. If people want to understand...

RESULTS Part A I can't see how many of the 165 patients were labelled as having long COVID for the Part A analysis - can anyone find that? That's interesting, no sex bias in the development of long COVID, although perhaps the sample was too small and Long Covid is defined loosely. So, they...

METHOD A. Mitochondrial gene analysis Hospitalised - but this was in 2020 when maybe everyone who was positive may have been hospitalised B. Relationship between Mitochondrial derived peptides (MDPs) and inflammatory markers Samples taken 4 weeks after infection. 20 Neurological-PASC (10...

University of Southern California

See this thread for the moved discussion on diagnostic tests: Biomarkers for ME/CFS - discussion thread on the next steps for testing biomarkers, and why we need them

The selection criteria is quite unclear. I think the sample is of people who reported having experienced at least one 'potentially traumatic experience'. But I haven't looked closely enough. I intended to, and then thought that maybe the study wasn't worth spending time on. It just all sounds...

PTE = Potentially traumatic experience

It's a nice article. As I was reading about the significant variation in human bodies, I was thinking about the misplaced certainty of the FND proponents when it comes to their diagnostic tests. If nerves can branch off in multiple different ways in different bodies, and it seems that they...

Thanks bobbler, it's probably time we aligned that list with the various threads we have, and checked the links still work. I'll add it to the to do list. If, after checking to be sure that there isn't an existing thread, anyone wants to start a thread for a clinic providing services to people...

Yes. I don't think they are necessarily a waste of time, it's just that they aren't science. People volunteer to tell their stories and are selective about what they say, there isn't a statistically valid result. Papers like this are really reporting, a type of journalism, and, if they are...

I feel a bit hesitant about this campaign against the #EveryBodyMoves idea. Yes, of course there is a big element of inspiration porn and yes, it is likely to make many people with ME/CFS feel sad about what they have lost, what they cannot now do. But, I'm not sure that we should campaign...

When I was talking about 'overall prevalence' I was meaning 'rate per thousand' or percentage. I wasn't suggesting people with ME/CFS diagnoses over the age of 60 should not be included in national totals. It's just that I think diagnosis in the older age groups is even more subject to the...

Thanks for posting @Daisybell. From the article: