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The 13 differentially expressed genes are between the SARS+F+ group and the SARS+F- group. That's good. Although 20 people is not a big sample.

So SARS+F+: 20 participants SARS-CoV-2 positive; high fatigue (numerical CFQ>=21); meeting WHO PCC and Fukuda criteria SARS+F-: 20 participants SARS-CoV-2 positive; low fatigue (numerical CFQ<=11); not meeting WHO PCC and Fukuda criteria SARS-F+: 20 participants SARS-CoV-2 negative; high fatigue...

:rofl: for the cat, and :rofl: for the fact that the abstract is three paragraphs long, but only addresses the title in the very last sentence. And that sentence looks as though it was nearly forgotten, an 'oh, and...'

I do wonder about the informed consent - did participants really understand that the results would be used to try to label their fatigue as a product of attentional and interpretational biases? I laughed about the comment about the welfare of animals. Because humans are animals and the authors...

Onto interpretation bias: The problematic information processing biases are taken as a given in ME/CFS, with the aim being to compare and contrast. Implicit Interpretation bias task To summarise, for each of 12 ambiguous scenarios, participants had to rate how similar 4 sentences were...

that can't be viewed outside the UK - what's the gist?

That's a sad story. The following paper says there isn't one particular part of the brain that causes neurogenic stuttering and even a small lesion can disrupt the neural network producing fluent speech. That suggests to me that neurogenic stuttering might easily be mis-diagnosed as an FND...

Ah, thanks @Andy, I had missed it. I'll merge them.

Thanks for posting the article. I've been working through blood pressure issues for and with my Dad. He's been tried on a few new medications to lower his blood pressure in addition to one he is already one, and they all came with significant side effects. A couple caused dizziness and...

Good to have you here JoClaire I think it is really hard to prove that ME/CFS isn't an FND while there is no diagnostic biomarker. Even then, then there are examples of people with clearly physical ailments being diagnosed with a functional overlay, either because their physical diagnosis...

WHO on the airborne nature of transmission of SARS-CoV-2: The biology of coronavirus COVID-19 - including research and treatments

That is something that I would contribute to, if someone got the people involved on board and set up a fund raiser.

Investigation of wearable technology that can better define symptoms and impact e.g. activity levels, ability to maintain concentration, ataxia

ME/CFS Patient registry studies to get better information about disease course

Multiple repeated exertion over a series of days – where participants exercise each day for up to 5 days – with wearables assessing activity and proteomics

Replication of the repeated CPETs, at a large enough scale to provide convincing evidence one way or another

Followup on Paul Hwang’s work on WASF3 in muscle cells/ unfolded protein response/ endoplasmic reticulum response to cellular stress

Investigation of changes in proteomics etc during pregnancy in ME/CFS, coupled with symptom monitoring. Does pregnancy have an impact on ME/CFS severity? Poll: Did pregnancy affect your ME?

GWAS followup to DecodeME

Post-mortem studies - brain and muscle and bone marrow histology, presence of pathogens