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Actually, NICE use GRADE and GRADE is garbage. There is no gold standard other than careful reasoning, when the chips are down. The difficulty is that dim people often find it hard to follow careful reasoning. Peter Barry has done a brilliant job of showing that all the complaints are spurious...

It is recognised by a group of people who like these catch-all predigested terms. As an immunologist I never used it or even came across it. I only met it in the context of ME debate. Terms like 'illness behaviour' are generally best avoided. They package up the immune response in ways that...

Brian Hughes might be interested in co-authoring. I am happy to, but not an expert in the area. There are one or two other senior members who might be ready to join in, although not chipping in just at present. I guess Treadway might or might not want to get involved but might join a letter...

Very possibly. But had he realised what F had as well?

This looks very interesting. It seems a pity they keep talking about inflammation. It looks to me that cGAS - STING and IFN-a may be involved in a protective or scavenging signalling response that, like complement in the circulation, may be more about anti-inflammation than inflammation. But it...

Is the punch line that HV F looks just like ME B? Cross posted. It seems not quite but maybe ME B was on to it?

Packaging immunological processes into pigeon holes like this has always been a bad idea. I cannot see merit in this one. It muddles together all sorts of different factors.

But the argument seems to be that it failed to deliver drugs targeting protein coding genes. And that was just because most of the genes had already been identified. There are scores of monoclonals targeting proteins and scores of kinase inhibitors targeting proteins. Johnjoe McFadden seems to...

I am afraid that maybe the robots have concluded that S4ME members are much too sensible to be worth putting it at the top of Google. And they will have established that the most expensive items that members buy are vegetable knives, earplugs and soup warmers!

I would prefer not to use terms like 'chronic immune activation'. The immune system is very complex and one cell's activation may be another cell's inhibition. I do suspect that abnormal signals are being sent in peripheral tissues - maybe especially gut and lymph nodes where lots of immune...

I don't see this as a big problem. The NICE reply will come up on PubMed with an abstract and all academics and physicians will be able to access it through institutions. Members of the public can otherwise access all they need through S4ME.

They aren't that invisible - they are mostly people who love the sound of their own voices and the beeps of their own Tweets. And the reply from NICE makes it clear that they are not necessarily all powerful. They have lost (at least for the moment). In a way they are simply a group of...

What I have managed to read of McFadden's review and the whole of the Guardian review leave me with no idea what this book is supposed to be saying. In fact masses of new treatments have come from discovering genes. It is just that most of the important genes were discovered individually before...

Simple answer, No. It sounds like something made up as a ruse to try to get you to get out more.

"It's not like you're not capable of doing it, but your body tells you don't do it" This is an awkward sentence for a start. I assume it would better be phrased with two 'thats'. It's not that you're not capable of doing it, but that your body tells you don't do it. This looks like it has...

It's a very interesting question. Is there constant alert signalling in peripheral tissues like muscle or is it purely central in hypothalamus. One thing that may be worth noting is that some cytokines and cell surface receptors get 'painted' on to tissue matrix. TGF beta, which is the cytokine...

Yes, this looks interesting. Studies of normal control mechanisms in mice form a bedrock for understanding human mechanisms. It is the study of putative disease pathogenesis that animal models are so misleading for. If TLR-7 induces brain changes without raising IL-1beta and that is sex...

I think there is a certain creative style in the ironic MEA reference to these, 50 plus, authors as 'a tiny minority of healthcare professionals'. This is presumably a reference to the tiny minority of militant ME activists, including the rabid MEA itself, who objected to CBT and GET. But to...

Oh, dearie me! A thread for the effort measure sounds a good idea. I would love to see conclusions but am unlikely to be able to follow the detail (even if because of lack of effort preference).

Yes but studies have implicated everything in everything. This looks like a PhD student essay with a few senior names on it. The abstract says nothing of interest so I am not going to read further I am afraid.