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Like having a government supported by organisations like SMC for scientific opinion is likely to kill tens of thousands of people? I haven't listened but I don't get this. The message is not wot she said at all. It is that scientific opinion-forming has completely lost the plot because...

Highlights of Fiona Fox director of the Science Media Centre at todays Inde Sage talking about lessons from the pandemic. Scientists should share evidence "not opinion or ideology", "not put themselves into camps or take a position" & the importance of humility. So who is she sniping at? Indie...

So these fibres are like charm bracelets. At regular intervals there are holes to plug in signals.

So these fibres are like charm bracelets. At regular intervals there are holes to plug in signals.

So all tissues are held together by a mixture of collagen and elastic fibres. In muscle, for instance, you have fibres forming networks like the net bags they sell citrus fruit in at various levels of structure - around bundles of a few muscle cells, around larger fascicles and around entire...

So all tissues are held together by a mixture of collagen and elastic fibres. In muscle, for instance, you have fibres forming networks like the net bags they sell citrus fruit in at various levels of structure - around bundles of a few muscle cells, around larger fascicles and around entire...

My memory is that it is fairly unpleasant to take. The blurbs say: Nausea, vomiting, diarrhea, abdominal cramps, increased saliva/mucus, blurred vision, decreased pupil size, increased urination, or increased sweating may occur. I think it also interferes with sleep.

But it is equally important in neural regulation of other things. I have not looked at this in detail but I wonder if they have information on normal controls in terms of pyridostigmine affecting peak VO2. It would be quite odd if it did it seems to me, but we need to know. I continue to be...

As far as I can see all the evidence quoted relates to shifts in cardiovascular measures 15 minutes after drinking a bolus in an artificial situation with negative lower body pressure as well as tilt. I don't think it is meaningful to say that it 'improves orthostatic intolerance' as if it was...

An RCT is not going to show how many PWME have PEM! It is just a matter of whether you define it that way or not. Presumably Dr B is thinking of 'fatiguing illness' in more general terms or just making it up.

I seriously doubt that. This is the usual pretence to know without knowing and selling of exercise that pervades the profession. Soft sell may be part of that but in some ways it is all the more worrying.

It can but I am not aware of any standardised method that would allow useful interpretation. You can see connective tissue fibres light up with all sorts of fascinating immune signalling molecules but how you measure that is another matter. It might be possible to standardise the signals...

I contacted the author who replied. So he knows there is interest. He is doing some experiments now.

I follow the view of Mike Murphy, mitochondrial researcher at my Alma Mater, Cambridge. Failure of respiratory metabolism in terms of ATP production does not really make sense for ME. If you cannot make ATP you find you cannot lift an arm or climb a stair but it does not make you feel ill like...

I follow the view of Mike Murphy, mitochondrial researcher at my Alma Mater, Cambridge. Failure of respiratory metabolism in terms of ATP production does not really make sense for ME. If you cannot make ATP you find you cannot lift an arm or climb a stair but it does not make you feel ill like...

The paper is longwinded but to me it is raises interesting possibilities. A big question for me is whether the perpetuation of ME can be put down to some dysregulation of brain cell signalling - maybe brainstem - or whether we really have to propose that peripheral target tissues like lymph...

Letter from NICE today: Dear Jonathan, Re: NICE statement on the implementation of the ME/CFS guideline Many thanks for submitting your comments on the GRIP implementation statement. This is now going through our review and approval process. We are aiming for a publication date of 12th...

The tweet about trolls is peculiar. Maybe these people have the same problem as the BPS crowd - some other people are on to them.

The conclusion in the abstract suggests that the authors have no real understanding of what it is they are trying to do. The more the lab results correlate with the clinical diagnosis, already made, the less use they are, since the simply give you the same diagnosis. Shifting to new lab based...

It is a very neat story. This is how real science works. Most lupus is probably not primarily due to a TLR7 abnormality but if TLR7 can be blocked it might break the cycle of lupus whatever the initial trip. It might also break the cycle for things like RA although it might turn out to not work...