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Critical Analysis of Psychological Illness Explanations The only certainty Is uncertainty: Doctors should admit when they don't have an answer Frances, A 2013 link to article This article argues that medical professionals are overconfident about their diagnostic abilities, and fail to...

Articles that highlight the problems/limitations of clinical trials in general (**=key article) Placebo effects are weak: regression to the mean is the main reason ineffective treatments appear to work. Colquhoun, D. (blog) 2015 link to blog Placebo Myths debunked. Novella, S. (blog) 2017 In...

You're right, @BurnA, the rules didn't change. Its just people have got sick of dodgy studies that adhere to the letter of the law (no outright fraud), but not its spirit. FFS, you shouldn't need to be told what the 'rules' are, you should know from your training how to avoid doing bad science...

Can patients with chronic fatigue syndrome really recover after graded exercise or cognitive behavioural therapy? A critical commentary and preliminary re-analysis of the PACE trial. Wilshire C, Kindlon T, Matthees A, McGrath S. Fatigue. 2017 Jan 5:1-4. link to article This article critiques...

2016 Cochrane review of exercise therapy for CFS: Exercise therapy for chronic fatigue syndrome. Larun L, Brurberg KG, Odgaard-Jensen J, Price JR Cochrane Database Syst Rev. 2016 Jan 1;6. link to article The Fine trial (PACE’s ‘sister study’, looked at more severe patients): Nurse led, home...

Publications from the PACE trial (**= key article, read this first) The PACE trial assessed the effectiveness of CBT and GET as treatments for CFS. Over 600 patients diagnosed with CFS according to the Oxford criteria (in which fatigue is the only required symptom) were allocated to four...