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Thanks for saving me the time @Utsikt , I need it just now.

Dear @tiredbutwired, I am a professor of medicine rather than a patient. I am interested in any theoretical suggestions but I am not interested in chasing lengthy expositions that cannot be summarised in a couple of sentences - simply out of politeness if nothing else. I don't think we have any...

There is a problem if 90% of cases are female since EDS is by definition autosomal dominant with equal sex incidence or sex linked recessive with a major male predominance. Women are more (joint) mobile than men so this seems likely to be a population of relatively mobile women who have sought...

This does not sound like a 'prospective cohort. You do not make diagnoses by 'chart review' in a prospective study. It is very unclear what the results should be compared to in terms of control or what biases may be involved in the acquisition of these patients by a clinic. Why start with a...

This seems very strange. It almost sems to be a recognition that German doctors need some placebos handy to deal with the LC patients. Atypical anti-depressants can produce some pretty horrific side-effects too.

If socks leave marks there is some extra fluid accumulating - oedema. Symmetrical or near symmetrical low grade oedema is very common as time goes by. For many people it does not appear until they are around sixty to seventy but for a proportion of people it occurs quite a bit younger. Nothing...

The whole thing seems to be based on a belief in a microclot type theory - where viscosity doesn't actually matter because the problem is clotting (where viscosity ceases to be relevant because the lump is solid). It is absurd to try to claim a change inviscosity without actually measuring it...

That does not make sense to me. If cortisol levels are normal the body is not robbed of anything surely? Especially if the body is made of cells that pick up cortisol even more than usual and there is a normal amount available outside the cells.

I randomly asked Google: How often do people fall ill on Thursdays? AI Overview While there is no specific scientific data suggesting people fall ill specifically on Thursdays more than other weekdays, Thursdays are sometimes associated with the, "leisure sickness" phenomenon, where symptoms...

I doubt much funding will go into it -certainly not from major funding bodies. It might get ten million from some billionaire with a whole family with MCAS.

But apparently not associated with orthostatic intolerance symptoms. What on earth do these people think they are saying? Haven't they just proved that these 'criteria' for 'POTS' are fairy tales? What I find so extraordinary about this is the lack of any imagination or creativity. It is...

More like homeopathy I think. They will require evidence of mast cell activation but the evidence required will be so small that it no longer can be identified (as mast cell activation). Criteria for ME/CFS do not require evidence of anything, just symptoms. The reviews on MCAS make it very...

One of the more sensible bits of the blog I would say. We were discussing whether we had whacked the B cells hard enough in the last century (just).

If you can't duplicate the reviews then why not review the duplication?

Either way that bit is seriously unimpressive. Maybe give them 6 out of 10.

Let's all be cynicial together. Poor old Ed, only a 'part-time professor'; so busy with more financial issues, perhaps. And only at McSmarmster University at that, it seems. Backscratchers by name...

Indeed, and I thought their last sentence was pretty good: These findings highlight the need for alternative approaches to understanding and treating long-COVID fatigue beyond conventional inflammatory paradigms.

I think that may be because they cannot move so they cannot test their semicircular canal and otolith function by finding differences on movement. The organ is likely to accommodate when static.

That is quite different because the pressure difference around your body in a submarine varies from head to toe only by the weight of some air in the submarine. If you fill the submarine with water your toes are subject to the pressure due to the weight of water between your head and your toes...

I am afraid that my take is given in post #3.