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That is reassuring.

Seems another interesting way of thinking about female predisposition.

Yes, Sonya seemed upbeat. The discussions on here in the last week also give me hope that the puzzle of the DecodeME treasure map may not be quite as obscure as it first seemed. There is work to do but things seem to be making a bit more sense. Those Mumbai-with-kite-flying-competition plots...

Yes, what worries me is that it may be biased by the number of papers noting expression in certain areas because they are trendy. I may be quite wrong but these things happen all the time.

A persistent whiff of cholesterol.

Perhaps this reflects the clientele at the Health Check-up Center of Shanghai Shuguang Hospital.

The figure floating around was £20M in total. I think the rough idea is to break it up into £5M segments or thereabouts.

With which I am quite sure Luis would entirely agree.

The neurofilament light chain finding is interesting. When talking to Mike Zandi from Queen Square I am fairly sure he said that he did not think the skin biopsy test for small fibre neuropathy was reliable. Theyir policy is not to do it. That might explain the lack of correlation.

Yes, but no details for public dissemination. I think Sonya would allow me to say that, as suspected, MRC has let us down, but sponsors are being engaged and that progress is being made. The strategy seems to be to break the project down into fundable segments, which makes sense to me. If...

So this seems to be making some sense. It doesn't look like fluff and there seem to be two different signals. It would be useful to know if the order of tissue expression levels was really telling us something or whether it reflects bias in the way information is collected.

That looks different enough for me. I guess there might be two effects operating with one common to the two analyses but one to the right but I still don't really have a feel for what these pictures of kite-competitions-over-Mumbai-plots mean in detail.

As it is, quite a lot of such people are known about by ME/CFS networks and if it was known that there was a policy within the community communication should not be impossible. If there were clinical research centres for severe ME/CFS, as we have suggested, then patients might well be known to...

Autopsy is quite rare nowadays and most often is performed when there is genuine uncertainty about cause of death. It might be performed in people who have committed suicide or starved, on top of ME/CFS, as a way of finding out more but I doubt the very considerable cost involved would be...

It seems odd that BTNs should crop up with anxiety. It makes me wonder whether it they are some of these adhesion-related ligands like VCAM-1 that have got used by entirely different cell systems for different purposes. Maybe they are involved in neurons too. The role in milk fat globules might...

He would be around 65. The Cambridge trail seems to run cold around 2015 but I might be able to find out more.

That takes us to a 2013 paper by Anne Cooke and John Trousdale. Anne is my age and was with me in the UCL immunology unit up until about 1992. John is younger and was primarily interested in NK receptors I think.

A quick look on AI. The NEGR1 (Neuronal Growth Regulator 1) gene, located on chromosome 1p31.1, encodes a GPI-anchored cell adhesion molecule critical for brain development, synaptic organization, and neuronal connectivity. Strongly associated with obesity, depression, and neurodevelopmental...

I am going to try to get a bit more information on this, although it may be strictly confidential. One thing that strikes me is that if the results for the drugs are negative then the open label format probably does not matter. Bias is pretty much always to a positive result. If we knew that...

Not sure. I think the possibility that the CRH cell findings are artifactual is probably an independent issue relating to histological methodology (not particularly sampling).