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It would be nice to think there are useful hints here but I am not optimistic. TGF beta is not mentioned and IL-8 was low (the two maybe up in ME/CFS). IL-6 is such a final common pathway signal that it could easily be a confounding comorbidity issue. IFN gamma is there but maybe better not...

I had a session with Ross Paterson on Thursday. Ross is a Queen Square neurologist researching CSF dynamics in relation to normal pressure hydrocephalus (NPH) at the Institute of Neurology. He probably knows as much about CSF flux as anyone at UCL. He seemed to think that my revised explanation...

Absolutely agree. But the government are just the people other people vote for to run things. In the UK it looks as if next time people might be voting for an even more dog-eat-dog system. Any Bevanite vision of a system devoted to the public good seems to be fading into the ether. The people...

The relation to sex determination sounds interesting in relation to the sex ratio issue. I am out of my depth here too but I suspect not - that the links are all ways of weighting the same relevant pathway a bit in favour of the pathological process in any given individual.

Surely there is nothing weird about that. Feeling guilty about eating chocolate is part and parcel of the fun. Especially when you agree to have two each and end up eating four.

I absolutely agree that it is the responsibility of the healthcare system rather than the patient and the inappropriateness of the text. However, the job of medics is to provide what health care they know is useful. The problem here is that nobody knows what that is and it needs research. And...

I note that I was ambivalent about interpreting the cohort for this study 6 months ago. Maybe it is a mixture of red herring and lemon sole and the task is to work out which for which genes. Despite the apparently impenetrable complexity of all the data I am getting the impression that with...

But they might feed signals to other cells telling them that resources are being stretched and then might send signals saying everything is OK now, after a delay period to make sure it really is, and that might backfire? We know that neural control systems are hugely complex in terms og knock...

Who are they kidding?

Absolutely. I used to keep hearing on 'educational' programs that you had to roast cocoa beans before you go the flavour at all. But in Colombia I was offered a ripe cocoa pod full of beans to suck out. It was absolutely delicious. It had that mysterious subtle flavour of white chocolate that I...

I am pretty sceptical that anyone could find a quadratic dose response relation. That sounds like bluffing with clever words.

But chocolate is yummy.

I have been discovering a use for AI generated summaries in biomedical research. The summaries tend to draw together review material and derive a positive spin narrative from them "Yes, IGF15 plays an important role in the control of guitar-playing." But in the process it picks out key...

The fact that recovery from Long COVID is rare means... Let's get some basic facts right, please. It is the norm, by a long way. I agree, with 'friends' like this* there is no need for enemies. * Which apparently includes the Patient Led Research Collaborative that provided this untruth in the...

In mice but intriguing. Maybe in PEM the neurons are backfiring.

They are just trendy. And people have been publishing shaky studies on associations with GPCR antibodies in all sort of conditions for a couple of decades. Maybe they are attractive because it seems you can weave all sorts of stories around them about symptom mechanisms. The difference from...

Nope. It is infuriating pseudoacademia.

OK, but without a proper trial improvements could mean anything - they are not 'responses'. The idea of an atypical enterovirus infection was raised by the claim of local neurological signs during the Royal Free acute epidemic illness and maybe also the Iceland epidemic. Subsequently it seems...

My cncern is that there are no studies that provide any meaningful evidence of benefit. The study quoted is useless.

If p=0.17 no way is this a 'coherent signature'.