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I think there is a basic mistake here in that they are targeting a monoclonal anti-IFN gamma in mice. Anti-IFN gamma i humans are likely to be polyclonal and a CAR T cell directed at one Ig species will not solve the problem.

I don't think this is 'just' clutching at straws. It is a very uncertain relation to NEGR1 but the p value threshold for the GWAS, as I understand it, has to be set high for multiplicity reasons and there are going to be lots of type 2 errors missing genuine links. I think the odds of there...

I didn't say their comments were always how one would like, but we do have one journalist in our midst who seems pretty on the ball!

All people with an interest in human nature can study it but that doesn't mean you need an academic discipline for it. Journalists are good at commenting. Novelists can illustrate and throw insight. i fail to see the need for students to be taught it as a 'discipline'. Especially if the...

The Pope was quite hard on Henry VIII's Church of England.

I might suggest closing the 'field' down. What possible merit does it have?

But there will always be reports like this, even for homeopathy tablets with nothing in them.

I note the comment in the Cheshire policy: Based on NICE guidance and other literature, there is no published evidence which would support admission to hospital for management purely of ME/CFS. This is factually wrong because it ignores the paper by Helen Baxter, Speight and Weir on the...

But without proper trials he would not have been in a position to judge. I doubt Dr Chia sells supplements simply to make a living. I think he may believe they do good. But if you do not have reliable evidence for the value of what you sell that is just as potentially harmful as doing it for...

I don' think we have any reliable evidence supporting this proposal. Please post speculations as speculations, not as if they were medical facts.

I don't follow the question. ME/CFS is not defined in terms of infection. It is a syndrome that sometimes follows a history of infection. I don't know whether you have it.

I thought the above image was fun. Moving on from cauliflowers I will suggest that the brain is much like a deck mop on boat, kept in a bucket of pure salt water and regularly squeezed. Any proteins brought on deck by seagulls can be washed out this way. I initially thought that the authors of...

But why?: The article argues for structural competency and a medical humanities component in chronic pain education and advocates for a greater feminist and disability-informed presence in vulvodynia research and activism. Rather than 'auto-ethnography' why not just say for God sake what a lot...

Sounds like the same disinformation campaign as the BACME protocol.

I think the way to change the narrative is what forestglip and hotblack and ME/CFS Scientist and utsikt and jnmaciuch and others are doing pulling apart the genetics until we see what is wrong.

No, but the populous might vote to say that healthcare and medical research in general need at least adequate funding. They might not but one can hope. And that is the central grouse against this article. It is part and parcel of the do-gooder touchy feely wellness humanities-type approach to...

Apologies for the technicality. I wanted to make this very short to get a simple point across for those in the field but even the reviews I cite are likely to be incomprehensible to a lay person because they assume the same background despite beign five times longer. In brief: It seems that...

That I would certainly agree with. It is part of a 'humanities' culture that pervades centre left media and poisons public debate. At heart it is the same dumb shamanism that underpins the BPS view. There is nothing sympathetic here, just self-serving pseudo-intellectualisation. The only thing...

I will try to direct message the review @ME/CFS Science Blog