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This seems to be re-inventing a wheel from the studies of the 1940s and 1950s and without much insight. The article linked contains lots of very doubtful claims about energy and rest. I think that thinking about ME/CFS would do well to move away from energy completely.

Getting artifactual results from counting cells such as mast cells, in tissue sections is very easy. The general presentation of the results does not inspire a lot of confidence. The title claim of 'Gut-Immune Axis Dysregulation' is immunobabble. I have never heard of a gut-immune axis. Most...

If its this one, I had direct access: link

Sounds about right.

That sounds a bit like discovering at coffee time that you put your boxer shorts on the wrong way round when you got up.

To actually announce that your study is non-randomised, as well as omitting that it is non-blinded and pretending it is effectively controlled seems like scraping the floor of the cellar under the barrel.

That looks like a typical plastic recyclable CV to me. What has he actually achieved - in plain English? Do we need re-posting of Twitterati here? My enthusiasm is further dampened by reference to Afrin and Blitshteyn I am afraid. Where is the actual science?

Oh, I'm sure there is a clause that allows that. ;)

Surely PEM would do fine for 'non-specific symptoms in more than one system'? I don't think people with diabetes would fit.

I don't see patents as being a significant incentive for Fluge and Mella. They have a personal commitment to try to solve a biomedical problem that at least for one of them is very close to home. They don't cut corners. They actually want to get a useful answer. They will have good salaries and...

We have discussed it quite a bit on the OLFM4 Genetics thread I think. DecodeME found a potential link to OLFM4 which is an olfactomedin. Olfactomedins seem to occur in various tissues other than the nose and mediate responses to chemicals.

Agreed. The other thing that seems too vague is the definition in terms of 'non-specifc symtpoms', which could be just about anything. I think the biggest problem is that the vast majority of physicians will never make this diagnosis or see the need to and so diagnostic rates are likely simply...

OK, but since we know that people are very unreliable about attributing cause and that many are suggestible to physicians proposed explanations, and chemical exposure is a pretty loaded word, I think it remains pretty shaky as diagnostic category.

I don't think they do. My impression is that MCS is handed out as a diagnosis to people who very likely have ME/CFS on the basis that the physician concludes from leading questions that chemicals were the cause. And ME/CFS does not work like that either. People with ME/CFS do not attribute...

I think there is a big difference. The prevalence of ME/CFS is now widely agreed to fall within a range of the sort we see for conditions like rheumatoid arthritis. The uncertainty is somewhere between twofold and five fold and getting nearer the twofold. Because of a large proportion of...

Somebody needs to make it clear that there is no therapy for anyone with any sort of fatigue. Therapy has nothing to do with any sort of fatigue. Abnormal fatigue has nothing to do with energy or exercise - in any known context. People lacking energy feel hungry or weak, not fatigued.

He might be forgetting fields where negative standards have been mandatory.

No, I can't remember why but to get people to talk openly one tends to need to have something to offer in return and I may have thought it was not timely.

Reminds me of Plato's cave. Our appreciation of the real world is merely seeing fleeting shadows on a wall MCTS1, E2F1... But that doesn't stop physicists ending up making predictions verifiable to 1 in 10^18. Somewhere in all this is a causal reality. I think we might find it but don't ask me...

Make believe medicine always had a more 'establishment' presence in Germany - or at least since the 1980s in my experience. They went on having departments working on bogus physiology in rheumatology long after everyone else had moved over to fairly good science. They were the last people to...