Search results

That is a bit different from a rehab set up. All doctors work alongside nurses and in the community there will be physios covering physio things and everyone will be happy. But that is not the same as being the token medic in a rehab centre with forty therapists all therapping patients for all...

This is fairly much the sort of story we were tossing about some months ago. I agree that it makes some sense. But these papers recently picked up on suggest more complex and interesting detail of mechanism. I agree with @jnmaciuch 's comments. Injecting into brains is not going to mimic real...

I find the video quite disturbing. I don't think the physician has a good grasp of ME/CFS. Why was assisted suicide allowed? I cannot see the justification in the circumstances. Who knows if the diagnosis was even valid? I think it is also troubling to be discussing individual cases. Perhaps I...

I had a look at the very beginning of the last video. I didn't want the distasteful experience of listening further. The presentation is clever, in that it will appeal to many people as sympathetic, down to earth and friendly. I would add that I actually have no issue with the initial claim -...

Intestinal interoceptive dysfunction drives age-associated cognitive decline 2026 Cox et al The other one has bells on.

That is the strange bit. Yes, ACTH will be up in infection I think. There is a rabbit loose but it may be a real rabbit and worth chasing.

I saw plenty of jumpy mice being non-mobile when I used to do animal experiments. Freezing still is a usual response to fear. But admittedly that isn't 'lethargy'. And maybe the local adrenergic signals are nothing to do with a systemic adrenergic response. I do think it is becoming complicated...

pretty much

Yes, I agree.

That sounds like the suggestion I made that you neatly annihilated months back. The plot is certainly thickened here. I think I may have lost it.

That further complicates things, suggesting that CRH neurons have an anti-inflammatory effect other than through corticosteroid. I wonder whether there is a problem with the 'sickness behaviour ' tag here. People often equate it with feeling nauseous and febrile and otherwise ghastly in us but...

Right. A permissive role that maybe goes with an apparently opposite protective role?

Except that it seems to work in non-biofilm cases? I think I see what you mean though. And if it isn't classical LPS and has to work indirectly that is also interesting.

There are precedents for this sort of paradox when it comes to the 'HPA axis'. For instance, corticosteroid treatment induces water retention but baseline corticosteroid is necessary for water excretion.

That is neat and makes good sense. So this is the surprising finding to me. I would expect CRH to be switched on but not to mediate the response. If this is right it seems as if there are branches to the causal tree around the CRH cell area that might be very significant. There was previous...

Just looking at the title and abstract it is a bit odd that the title talks of biofilm when the findings seem not to relate to biofilm - just polysaccharides, which have always been implicated in 'sickness behaviour'. It would be interesting if CRH was involved. It seems surprising, since CRH...

It sounds like it but these people are already there so what is 'building a network'? I am pretty sure it is indoctrinating people with care policies that cast the referral centre in a glowing light. And what is this 'collaborative' if not referring to some other professional for maybe a bit of...

There is, but always used to justify services. Maybe patients require compassionate informed medical support but what medical support is being implied? In general the support needed is just care, or access to nutrition. Does effective care involve 'building a collaborative network" or does it...

I agree that this Guide needs more scrutiny. There was a presentation on it at the ForwardME AGM by the BHC manager. I raised the issue of how problematic it was in a later message. It is clearly regarded as 'on side' by many patients and advocates but typifies the make-believe 'support' that...

I think ME/CFS is a lot more than just PEM. In fact I think one could reasonably define the population with ME/CFS as conforming to a syndrome without any reference to PEM. PEM is an interesting aspect but I think it may be overemphasised. I agree that MCS in the sense of a syndrome of feeling...