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  1. Jonathan Edwards

    Evidence of White Matter Neuroinflammation in [ME/CFS]: A Diffusion-Based Neuroinflammation Imaging Study 2026 Yu et al

    I had a quick read through and found it very hard to see any data in an intelligible form. That may just be the way recent fashions in presentation go against the way I am used to reading papers but I am not so sure.
  2. Jonathan Edwards

    Persistent physical symptoms not explained by structural abnormalities or disease processes: a primary care approach [..] recovery, 2026, Abrahamsen+

    Maybe, maybe not. It is common enough for CBT and other psychotherapists to poison relationships with suggestions of abuse where there was none to the extent that families can be completely destroyed. I have winessed examples at close hand. There are important differences in detail for sure...
  3. Jonathan Edwards

    Persistent physical symptoms not explained by structural abnormalities or disease processes: a primary care approach [..] recovery, 2026, Abrahamsen+

    I think the bottom line here is that a conflict of interest is not defined by a list of examples, it is defined by a conflict of interest. We all know what that is - potential benefit accruing to the individual influenced by the writing of an article or, in particular, the way it is written. It...
  4. Jonathan Edwards

    News from The Netherlands

    This sort of thing does not stop people like Fluge and Mella pushing things forward. It is disappointing but maybe unsurprising.
  5. Jonathan Edwards

    Persistent physical symptoms not explained by structural abnormalities or disease processes: a primary care approach [..] recovery, 2026, Abrahamsen+

    The NHS is almost identical to the system Landmark works alongside!! We all know the USA system is an anomaly!
  6. Jonathan Edwards

    Persistent physical symptoms not explained by structural abnormalities or disease processes: a primary care approach [..] recovery, 2026, Abrahamsen+

    Not for a salaried NHS physician. Trials can fail and you still need the physician to make diagnoses and advise. I was never paid to provide treatments. I was paid to give the best advice I could. Someone else got paid for the treatments. In the US I suspect nothing like this occurs because...
  7. Jonathan Edwards

    Clinical relevance of circulating blood microaggregates and reactivation of Epstein Barr Virus in long-term Post-CoVID syndrome patients, 2026, Wick+

    Exactly, it does not apply to this subpoopulation. They do not have microemboli. So the findings in the paper do not fit with their petechiae. Maybe I should have said for starters that people with microemboli of the size described will have splinter haemorrhages and local organ lesions of a...
  8. Jonathan Edwards

    Clinical relevance of circulating blood microaggregates and reactivation of Epstein Barr Virus in long-term Post-CoVID syndrome patients, 2026, Wick+

    That may be the case but people with 100 petechiae from microembolism are in general on the intensive care unit with renal problems or stroke. Normal petechiae are not due to microembolism.
  9. Jonathan Edwards

    USA: Mount Sinai PACS clinic and Dr David Putrino

    So these aren't early results.
  10. Jonathan Edwards

    Clinical relevance of circulating blood microaggregates and reactivation of Epstein Barr Virus in long-term Post-CoVID syndrome patients, 2026, Wick+

    It is normal to have some petechiae. It is normal to have a few splinter haemorrhages. But people with microemboli have more and they look a bit different. The distribution is also different.
  11. Jonathan Edwards

    USA: Mount Sinai PACS clinic and Dr David Putrino

    Well if he 'shared early results' it wasn't triple blind, was it? I can guarantee that a low level magnetic field will have no useful effect on neuroinflammation that isn't there. This is a situation where the mind has to be kept open enough for the brain to fall out.
  12. Jonathan Edwards

    Persistent physical symptoms not explained by structural abnormalities or disease processes: a primary care approach [..] recovery, 2026, Abrahamsen+

    I don't think it is. I think CBT therapists would be in the same ballpark as Landmark, although if Landmark gets paid to teach people to do LP that would be an additional conflict.
  13. Jonathan Edwards

    Persistent physical symptoms not explained by structural abnormalities or disease processes: a primary care approach [..] recovery, 2026, Abrahamsen+

    Not quite. An NHS doctor is paid to advise patients what they think will be useful for them. They get no fee for advising on any treatment, above what they get for saying sorry, there is nothing I think is of use to you (which I did several times a day every clinic I ever ran. Therapists are...
  14. Jonathan Edwards

    Elimination diets

    Yes, but all of them are always mentioned in any review about anything these days! Whether or not they are meaningful.
  15. Jonathan Edwards

    Persistent physical symptoms not explained by structural abnormalities or disease processes: a primary care approach [..] recovery, 2026, Abrahamsen+

    I think there is a significant difference. Doctors within health care systems are paid to offer whatever help to apatient they think might be of use, including saying sorry I don't have a treatment for your case. Landmark is paid to provide a specific modality being promoted. Similarly...
  16. Jonathan Edwards

    Elimination diets

    I don't have any bright ideas to add other than these experiences do tend to suggest that severe symptoms can be reversible. That may often be temporary but it does argue against a permanent structural basis.
  17. Jonathan Edwards

    SIBO - Small Intestinal Bacterial Overgrowth

    My impression has been that a definite diagnosis is hard to be sure of except perhaps where there are specific structural problems like post-surgical loops and scleroderma. Wkikpedia says: Nevertheless, as of 2020, the definition of SIBO as a clinical entity lacks precision and consistency; it...
  18. Jonathan Edwards

    Preprint Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome, 2025, DecodeMe Collaboration

    Yes, I saw that. I wondered if homing in on the tryptase area and IgE there might be some weak signals that might possibly be real and come out with a significant value if a targeted study just looked at those. Or nothing at all. It would likely be a wild goose chase but a solid negative could...
  19. Jonathan Edwards

    Preprint Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome, 2025, DecodeMe Collaboration

    I was meaning IgE genes - wherever they are, which is Ch14 at least for the constant heavy chain gene. I don't know much about the IgE genes.
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