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Editor’s summary Autoantibodies generated against extracellular antigens, including cytokines, can lead to immune dysregulation and secondary immunodeficiency. For example, patients with neutralizing autoantibodies against interferon-γ (IFN-γ) (nAIGAs) display increased susceptibility to...

"Immune Reset"Rebooting the immune system by depletion of B cells, like a reboot of a computer, to achieve cures vs autoimmune diseases“ Seems like your cells become less colorful with CAAR therapy….

Paywalled The emergence of potent depletion therapies for the treatment of refractory autoimmunity has led to the concept of immune reset. Understanding whether immune reset equates to cure, and whether cure is achievable through non-depleting approaches, depends on the identification of...

“Rachel Graves said Metrodora’s mission to cure complex chronic conditions was simply unattainable. “The dream of Metrodora was never possible because they promised something that was ahead of the science,” she added. “Telling us they could help us was either incredibly naive or a lie.”

Immortal with or without ME/CFS? Immortal with…not worth $1M.

Today, we are launching Immortals. + $1,000,000 per year + Three spots available Immortals is the world’s best health program. It is the exact protocol I have followed for the last 5 years. It is your Autonomous Health. Includes a dedicated concierge team, BryanAI 24/7, extensive...

Should have been a gift link.

Researcher skeptical of ‘Havana syndrome’ tested secret weapon on himself In 2024, a Norwegian researcher skeptical that pulsed-energy weapons could do damage to human brains built a device and tested it on himself. It didn’t go well. https://wapo.st/4kwZhEg

HHS Secretary RFK Jr:“I'm not scared of a germ. I used to snort cocaine off of toilet seats.”

Abstract CD38 is highly expressed on various immune cells, including long-lived plasma cells, making it a potential therapeutic target in autoimmune diseases. This phase Ib/IIa study aimed to explore the safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy of CM313, an anti-CD38...

Phase 2 is generally the hardest phase to get through. Drugs with a lot of funding behind them and preliminary results that look like a slam dunk frequently don’t make the cut. From AI: The overall likelihood of approval (LOA) for a drug entering Phase I clinical trials is low, generally...

“ 30 million is a rounding error in modern science — well under 0.1% of the NIH budget — yet it’s being framed as a civilizational pivot. France (and much of Europe) already struggles with entrenched cronyism, groupthink, and reproducibility problems in its research institutions. Adding a...

Highlights • Sleep deprivation triggers intestinal stem cell dysfunction and gut pathologies • Overactive dorsal motor nucleus of vagus transmits sleep defect signals to the gut • Excess acetylcholine from vagus nerve triggers 5-hydroxytryptamine spike in the gut • Elevated 5-hydroxytryptamine...

Do Americans not eat marmalade? FOOD & DRINK I was buying marmalade at my local Safeway yesterday, and the cashier said, "Ooh, marmalade! No one buys that. I like it, myself, but I've never seen anyone else buy it". My husband and I are imports, we grew up British so we brought our weird...

Is this U.K. speak meaning that this statement is obvious?

No—Topol is actually (shockingly) being good/helpful here. He is criticizing Attia for hawking this bogus AG-1 supplement and these David protein bars, etc. “Moreover, these days you are riddled with conflicts as a huckster for David Bars, AG-1 supplement, and so many other things that diminish...

Happening right now—google Peter Attia. He is getting dumped on for the main thing in the news, but also a result of being in the news, people are criticizing his bogus longevity claims. Here is Topol attacking Attia: “ Good that you posted a response, Peter. Agree, there is no defense for...

Not really. Well working with very small sample sizes here. For non-responders: Patients 3 and 9 weren’t able to reduce IGG much—8.2 and 7.7 at 5 months. Patient 4 was able to reduce IGG to 3.7 at 5 months but started at the lowest level—6.8. By month nine patient 6 was above 7 and the...

Svetlana disagrees. Hot off the press: my new paper that moves this field forward and changes the narrative on what #POTS, #MECFS and #LongCOVID are... Neuroimmune Disorders! The brain and the autonomic nervous system are involved in the immune system regulation. There is evidence of...

Merged post https://substack.com/@erictopol/note/c-208424475?r=7y4i4&utm_medium=ios&utm_source=notes-share-action Might be of interest to @Jonathan Edwards