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And it helped you in the past? With which symptoms and about how much improvement?

I’m not sure who prevailed in the genetic discussion or whether it was resolved. Regardless of mechanism, a well documented n=1 case history of symptom improvement is always welcome. If the there is an improvement in the more common genotype that means that it is possible spiro might work for...

Opipramol comes up again. Hmmmm.

I agree with not speculating about mechanisms. Howver, I do think it is important to keep track of anecdotal reports, especially on non-common meds.

“Just to reiterate: since Imatinib i am still symptomfree (aside from tinnitus), and importantly: my emotional state or mind-body relation or predictive brain relation etc did NOT matter. It is a simple case of less bloodcell activity.”

Post in thread 'Spironolactone for viruses - personal experience gathering' https://forums.phoenixrising.me/threads/spironolactone-for-viruses-personal-experience-gathering.84082/post-2427192

Gaffney “There is no society-wide brain degradation occurring because of ongoing mild Covid infections which will continue to the end of time. These accounts cause significant distress for a small but not irrelevant share of the population.”

Abstract Chimeric antigen receptor (CAR) T cell therapy was recently proposed as a treatment for adults with B-cell-mediated autoimmune diseases (ADs) refractory to conventional immunomodulatory therapy. We present a case series of eight children with severe/refractory AD (four systemic lupus...

Only one month at 100mg. It seems like she had no response during titration—probably 25, 50, 75 and then 100mg. It seems a little strange that she had no response until she hit exactly 100mg—but life is strange.

What is the best commercial kit to test for this gene? Thanks.

She suggests eplerenone for men. https://en.wikipedia.org/wiki/Eplerenone

Google AI dump from a search of rs5522CC

Saw this: Note: In some research literature, the C allele (Isoleucine) is the common allele, and G (Valine) is the variant.

Hmmmm…Chat GPT does bad.

The author is the patient. ETA—Oops @forestglip just noted this also.

Cool video I think alone time ratings will vary a lot depending on the introvert/extrovert level of the person. Regardless of ME/CFS status, introverts tend to find social interactions/excessive stimulation as energy draining—just like ME/CFS itself.

First author https://angelakeke.github.io/

AI succeeds in diagnosing rare diseases An artificial-intelligence system uses clinical data, genetic information and literature searches to suggest diagnoses and provides the underlying reasoning. https://www.nature.com/articles/d41586-026-00290-9 PW

Abstract Rare diseases affect more than 300 million people worldwide1,2,3, yet timely and accurate diagnosis remains an urgent challenge1,3,4,5. Patients often endure a prolonged ‘diagnostic odyssey’ exceeding 5 years, marked by repeated referrals, misdiagnoses and unnecessary interventions...

Topol is just quoting John Isaacs, the author of the article. He is a professor of clinical rheumatology /RA specialist from New Castle University. Do you know him? https://www.ncl.ac.uk/medical-sciences/people/profile/johnisaacs.html Professor John Isaacs Professor of Clinical Rheumatology...