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IIRC @Jonathan Edwards said somewhere on here that it is less likely to have a second AI disease diagnosis if you have one already. I have a friend who claims (and her doctors tell her) that she has MS, Sjogrens, Crohns, and another AI disease she doesn’t recall the name of. In this really...

OK thanks—and then after 3 months or so did their symptoms stabilize (flatten) or was there continued improvement in their symptoms over the following year plus as in the attached figures from the Fluge Dara paper?

@Jonathan Edwards In your RA trials with ritux, of the responders, were the first patients to notice a response typically the most severe patients or the most mild? Or was there no pattern? Thanks.

Except the Twitter guy who responded strongly to Dara had very low NK cell #. So who knows.

Not sure—can’t read paper now. Most of the responses in cyclo and Dara are long ramps not cliffs, so my point is that waiting longer makes sense in that you can see the full effect. If you give drug X to 2 ME/CFS patients one with a Bell score of 10 and one with a Bell score of 90, do they...

Not a mab, but IIRC the response for cyclo was around 6 months in the Fluge study.

I think I’ve changed my mind about some of this. At first I thought a shorter study is better to get it done with. But now with certain people taking longer to respond to Dara (~6 months like the Twitter guy with SJ + ME/CFS) I think longer is better to tease out delayed/late responders. But...

Last post on the dog that wasn’t really cured. “ According to the story, the dog's cancer has not been cured. • Absent all regulatory and manufacturing constraints, we could not just synthesize magic mRNA cancer cures. The technology is very promising, but it's not yet any kind of panacea. •...

https://www.writingruxandrabio.com/p/the-bureaucracy-blocking-the-chance “The story about bureaucracy almost stopping a man from treating his dog’s cancer with an mRNA vaccine went viral. The problem transfers to humans: we’ve made these clinical trials unnecessarily hard, denying hope to...

“Sorry to be the downer because this is an impressive story in some senses. But it is ~trivially easy to make a single mRNA vaccine. It's not hard. I cure mice of various cancers with various therapeutics all the time. I've made mice lose more weight in a month than tirzepatide does in a year...

We should be as lucky as the dog.

https://www.theaustralian.com.au/business/technology/tech-boss-uses-ai-and-chatgpt-to-create-cancer-vaccine-for-his-dying-dog/news-story/292a21bcbe93efa17810bfcfcdfadbf7

I have been taking Pregabalin for almost 3 years (saved my life). I thought about why it might work (GABA/Glutamate). To test it, I started Lamotrigine, works wonders. And now I see this preprint by Wirth/Scheibenbogen. @C_Scheibenbogen: for me it works, subgroup?

Why are you saying this?

I don’t think Siobhan is that active on this forum anymore.

It was based on this source. https://arxiv.org/pdf/2107.03611

“Most microbiome research is bad. Gut microbiome research is no exception.Only 44% of the field's predictive models are validated in any way, and only 8% have proper validation at that.You can safely dismiss practically all of this work.”

It would have been helpful if in the abstract they indicated which specific MCAS symptoms improved in the study.

Abstract Introduction. Idiopathic mast cell activation syndrome (MCAS) is an immunologic disorder characterized by inappropriate activation and degranulation of mast cells. Similar to other mast cell disorders, such as systemic mastocytosis (SM), MCAS can have very diverse clinical...

Natural killer cells as biomarkers for disease activity, lupus nephritis, and time to remission in treatment-naïve childhood-onset systemic lupus erythematosus: a cohort study, 2026, Luo et al Natural killer cells as biomarkers for disease activity, lupus nephritis, and time to remission in...