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Not optimistic https://en.wikipedia.org/wiki/Trimetazidine

Hypertension not MECFS, but pretty interesting. Highlights • The serum α-lipomycin level and fecal mRNA level of LipReg4 are elevated in HSD mice • S. aureofaciens Tü117 increases the serum α-lipomycin concentration and BPs in mice • α-lipomycin impairs vasodilation and increases BPs relying...

The search function is your friend. ETA there has already been a lot of discussion of this individual.

This conference looks good except for P*trino. Is anyone here going to this? It looks like the 2nd day will be posted later to youtube, but not the first day? No livestream, correct? Thanks.

Merged thread Simmaron’s Rapamycin ME/CFS Trial Moves Forward: The Goal – FDA Approval Cort Johnson https://www.healthrising.org/blog/2025/02/01/simmarons-rapamycin-chronic-fatigue-fda-approval/ Gunnar Gottschalk, the primary investigator, reported that with most of the results in, a...

The largest medical #AI randomized controlled trial yet performed, enrolling >100,000 women undergoing mammography screening, was published today @LancetDigitalH The use of A.I. led to 29% higher detection of cancer, no increase of false positives, and reduced workload compared with radiologists...

I think the resistance is only relevant to multiple myeloma.

AI better than physicians. (With Eric Topol) https://www.nytimes.com/2025/02/02/opinion/ai-doctors-medicine.html?unlocked_article_code=1.uE4.wkmS.QQLbYp-tLvFt&smid=nytcore-ios-share&referringSource=articleShare

Abstract Anti-CD38 monoclonal antibodies like Daratumumab (Dara) are effective in multiple myeloma (MM); however, drug resistance ultimately occurs and the mechanisms behind this are poorly understood. Here, we identify, via two in vitro genome-wide CRISPR screens probing Daratumumab resistance...

Cost is about US $15/pill

https://www.fiercepharma.com/pharma/vertex-scores-fda-nod-long-awaited-non-opioid-pain-reliever-journavx So approved for acute pain, not chronic pain. What about chronic acute pain??? https://www.cnbc.com/2025/01/30/fda-approves-vertex-non-opioid-painkiller-drug.html

From Ingrid Rekeland’s dissertation on the cyclophosphamide trial and from recent data from the Daratumumab trial it appears that patients with high IGG levels don’t respond to treatment(s), more data collection/deeper dive on this would probably be useful...

A week of pain and confusion for medical researchers https://wapo.st/4aEKtOU

Does this have finding have implications for the plasma cells that derive from these B cells? Any chance they will be abnormal?

Yes, that was sarcastic.

He is a cutting-edge Long Covid researcher!!

https://bsky.app/profile/putrinolab.bsky.social/post/3lfvd7ciapc25 Since my episode with the wonderful @longcovidanswer has been released highlighting viral persistence as a major driver of some #LongCOVID pathology, I’ve been asked repeatedly, “what should we do about it?” - totally fair...

It’s muddied the waters. I believe I made a thread about this on here. For example, AP has brought in a bunch of money for LC research but it’s my understanding it’s mostly going for viral stuff, which I don’t believe will help us. If she gave this money to Fluge or Ron Davis’ group then that...

FWIW, this recent preprint also noted significant differences between severe and mild/moderate patients albeit with different markers...

“Long COVID” with the symptoms of MECFS is MECFS, by definition. MECFS is agnostic as to the trigger.