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  1. J

    Shingles vaccines, chickenpox, Shingrix

    GSK studying if best-selling shingles vaccine lowers dementia risk https://www.reuters.com/business/healthcare-pharmaceuticals/gsk-studying-if-best-selling-shingles-vaccine-lowers-dementia-risk-2025-03-25/ Interesting.
  2. J

    The Complex Disorders Alliance (CODA) formerly The Metrodora Foundation

    Wow, since I posted this last year, it seems that the reviews have gotten substantially worse!
  3. J

    Impacts of the 2024 change in US government on ME/CFS and Long Covid

    https://www.nytimes.com/2025/03/24/health/nih-doge-trump.html?unlocked_article_code=1.6U4.H-Id.NLU4Xmq2zedT&smid=nytcore-ios-share&referringSource=articleShare ‘Chaos and Confusion’ at the Crown Jewel of American Science Senior scientists at the National Institutes of Health fear that research...
  4. J

    Medical Mysteries: After 18 years, a writer’s insights and farewell (On 'How doctors think' by Jerome Groopman)

    https://wapo.st/4iQGkKN Ask questions, especially ‘What else could this be?’
 Doctors increasingly face relentless time pressures, which may facilitate diagnostic errors. Common pitfalls include stereotyping, in which a doctor makes a snap judgment based on negative characteristics, and...
  5. J

    Doctors Told Him He Was Going to Die. Then A.I. Saved His Life.

    Scientists are using machine learning to find new treatments among thousands of old medicines. https://www.nytimes.com/2025/03/20/well/ai-drug-repurposing.html?unlocked_article_code=1.5k4.8QFK.wor_LdM-hIJS&smid=url-share
  6. J

    An In-Depth Exploration of the Autoantibody Immune Profile in ME/CFS Using Novel Antigen Profiling Techniques, 2025, Germain et al.

    Please dear God, don’t let me be afucosylated, anything but that! Was asking about the IGG because we saw that in the Fluge studies, the patients who recovered started and ended with lower IGG levels.
  7. J

    An In-Depth Exploration of the Autoantibody Immune Profile in ME/CFS Using Novel Antigen Profiling Techniques, 2025, Germain et al.

    What are these “IgG with inflammatory glycan patterns, for example, afucosylated IgG.”? From here: “Given our results and the existence of discrepant reports of elevated and lower levels of ADRB2 AAb levels, as addressed in the previous paragraph, the success of IA in responding ME/CFS subjects...
  8. J

    Unutmaz post about AI model use for MECFS

    From his post “I was hesitant to share the treatment, but I received permission from my friend. The treatment was Anakinra, which inhibits a cytokine called IL-1 that is highly pro-inflammatory. However, this treatment could be highly specific to certain patients, as mentioned earlier, and may...
  9. J

    Unutmaz post about AI model use for MECFS

    @Jonathan Edwards was negative-ish on anakinra https://www.s4me.info/threads/germany-greece-italy-spain-safety-and-efficacy-of-anakinra-treatment-for-patients-with-post-acute-covid-syndrome-precision.41474/
  10. J

    Unutmaz post about AI model use for MECFS

    Anakinra https://en.wikipedia.org/wiki/Anakinra
  11. J

    American Science Should Take a Lot More Risks—NY Times

    https://www.nytimes.com/2025/03/19/opinion/doge-nih-science-america.html?unlocked_article_code=1.5E4.WUrw.-fvT1NFmi_4K&smid=url-share The N.I.H. should pioneer a new funding mechanism to support scientific organizations with the flexibility to build that kind of infrastructure. In other words...
  12. J

    Impacts of the 2024 change in US government on ME/CFS and Long Covid

    https://www.statnews.com/2025/03/19/myalgic-encephalomyelitis-chronic-fatigue-syndrome-columbia-program-shutdown/ ME/CFS research program shuts down at Columbia after Trump cuts Not good NEW: Cuts to Columbia University funding have shuttered a prominent research center into ME/CFS, a...
  13. J

    USA: Center for Solutions for ME/CFS - news and updates from Columbia University's NIH funded center, Lipkin

    Copied post https://www.statnews.com/2025/03/19/myalgic-encephalomyelitis-chronic-fatigue-syndrome-columbia-program-shutdown/ ME/CFS research program shuts down at Columbia after Trump cuts Not good NEW: Cuts to Columbia University funding have shuttered a prominent research center into...
  14. J

    Chinese scientists turn tumours into ‘pork’ in radical cancer treatment

    https://www.scmp.com/news/china/science/article/3302422/chinese-scientists-turn-tumours-pork-radical-cancer-treatment Sounds good!
  15. J

    Has there been a review of ME/CFS treatment randomised trials since the NICE 2021 review?

    Yeah there are scads of unneeded review papers. A way to deal with this is to have promotion committees not award points for useless review papers.
  16. J

    Well-known, famous people with Covid-19 and Long Covid

    Don’t know if this post belongs in this thread…. Celtics' Porzingis excels in return from 'frustrating' illness https://www.espn.com/nba/story/_/id/44270352/kristaps-porzingis-excels-return-frustrating-illness "It was extremely, extremely frustrating, just not knowing what I had," said...
  17. J

    Oxidative Stress is a shared characteristic of ME/CFS and Long COVID, 2025, Shankar, Bonilla, Davis et al.

    Was this ever published? Close to a year now since posting the preprint.
  18. J

    Impacts of the 2024 change in US government on ME/CFS and Long Covid

    How a quack TV doctor made it to Washington. https://www.nytimes.com/2025/03/14/opinion/dr-oz-medicare-medicaid-trump.html?unlocked_article_code=1.304.M4c8.z-nwlst2WdaO&smid=nytcore-ios-share&referringSource=articleShare
  19. J

    Tropoflavin for brain fog

    Here is a prodrug of the above compound called R13–don’t know if there is any human data. https://en.wikipedia.org/wiki/R13_(drug) https://www.pnas.org/doi/10.1073/pnas.1718683115
  20. J

    Tropoflavin for brain fog

    Some people are reporting improvements in brain fog with this supplement. It’s available on Amazon as dihydroxyflavone. https://en.wikipedia.org/wiki/Tropoflavin Here is a paper https://pmc.ncbi.nlm.nih.gov/articles/PMC9881092/
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