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  1. J

    Daratumumab, isatuximab (CD38 drugs)

    From Nigeria press release Darzalex is a cold-chain product and is not registered in Nigeria. Isn’t it concerning that Dara is not available for multiple myeloma in a country of 240 million people?
  2. J

    Daratumumab, isatuximab (CD38 drugs)

    Russian Dara biosimilar—should be released soon. https://biocad.ru/products/onco/daratumia
  3. J

    Daratumumab, isatuximab (CD38 drugs)

    Unauthorized Dara in Nigeria https://nafdac.gov.ng/public-alert-no-031-2025-alert-on-the-presence-of-an-unauthorized-unregistered-darzalex-daratumumab-1800mg-15ml-vial-sc-injection-in-nigeria/
  4. J

    CD19 CAR-T cells for treatment-refractory autoimmune diseases: the phase 1/2 CASTLE basket trial 2026 Muller et al

    Abstract Chimeric antigen receptor (CAR)-T cells are considered a powerful therapeutic tool to reset the immune system in patients with autoimmune diseases. Innovative trial designs are needed to allow feasible testing of the safety and efficacy of CAR-T cells in clinical studies. CASTLE (CAR-T...
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    Chimera: An Open Source RNA Pipeline for Long Covid Research

    “ I spent about 200 hours over the last two months building an RNA pipeline to analyze my own long covid blood RNA sample. This post talks about my efforts and the end result. While I plan to open source some of this at some point, until I get more data, I'm unable to refine it enough to...
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    Chimera: An Open Source RNA Pipeline for Long Covid Research

    https://duanestorey.com/posts/chimera-an-open-source-rna-pipeline-for-long-covid-research.html Guy doing his own research.
  7. J

    Open USA 2024: Want to participate in MAESTRO? Chronic Lyme; Long Covid

    “Reviewers said, this sounds like a fishing expedition…..” Hmmm
  8. J

    Increased Numbers of CD4 + T‐Cells in the Hypocretin/Orexin Region of Narcolepsy Type 1, 2026, Shan et al

    Why do 'sleep attacks' happen? Study points to an autoimmune trigger in narcolepsy https://medicalxpress.com/news/2026-03-autoimmune-trigger-narcolepsy.html
  9. J

    Increased Numbers of CD4 + T‐Cells in the Hypocretin/Orexin Region of Narcolepsy Type 1, 2026, Shan et al

    Narcolepsy type 1 (NT1) is presumed to be an autoimmune disorder caused by hypothalamic loss of hypocretin (Hcrt; orexin). In postmortem NT1 brains, we observed an 11‐fold increase of CD4 + T‐cells in the Hcrt region compared with control hypothalami, without a corresponding rise in CD8 +...
  10. J

    Preprint Bezisterim-associated anti-inflammatory epigenetic modulation of age acceleration and Alzheimer’s disease genes Reading et al

    Bezisterim-associated anti-inflammatory epigenetic modulation of age acceleration and Alzheimer’s disease genes Abstract Abstract Treatments with the ability to slow or reduce biological age have therapeutic potential in diseases of aging, including late-onset Alzheimer’s disease (AD). We...
  11. J

    An exploratory analysis of bezisterim treatment associated with decreased biological age acceleration… 2025 Reading et al

    An exploratory analysis of bezisterim treatment associated with decreased biological age acceleration, and improved clinical measure and biomarker changes in mild-to-moderate probable Alzheimer's disease Abstract Introduction Aging is the primary risk factor for sporadic Alzheimer's disease...
  12. J

    USA: Mount Sinai PACS clinic and Dr David Putrino

    “Hi! We are slated for first-in-human mitochondrial transplantation this year. AND my announcement about the MMT therapy was 100% home-based. I’m excited to provide all sorts of options to all patients. My role is to build functional, actionable toolkits, not to sell magic bullets” Putrino...
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    Evidence of White Matter Neuroinflammation in [ME/CFS]: A Diffusion-Based Neuroinflammation Imaging Study 2026 Yu et al

    Good to know we can get our microglia replaced! I can breathe a sigh of relief. The evolution of microglia replacement: A new paradigm for CNS disease therapy https://www.sciencedirect.com/science/article/pii/S1934590925004072
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    Evidence of White Matter Neuroinflammation in [ME/CFS]: A Diffusion-Based Neuroinflammation Imaging Study 2026 Yu et al

    Is someone able to summarize the discussion here in simpler English at some point for those of us with lower IQ’s? Are the study’s findings debunkable?
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