From Nigeria press release
Darzalex is a cold-chain product and is not registered in Nigeria.
Isn’t it concerning that Dara is not available for multiple myeloma in a country of 240 million people?
Unauthorized Dara in Nigeria
https://nafdac.gov.ng/public-alert-no-031-2025-alert-on-the-presence-of-an-unauthorized-unregistered-darzalex-daratumumab-1800mg-15ml-vial-sc-injection-in-nigeria/
Abstract
Chimeric antigen receptor (CAR)-T cells are considered a powerful therapeutic tool to reset the immune system in patients with autoimmune diseases. Innovative trial designs are needed to allow feasible testing of the safety and efficacy of CAR-T cells in clinical studies. CASTLE (CAR-T...
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I spent about 200 hours over the last two months building an RNA pipeline to analyze my own long covid blood RNA sample. This post talks about my efforts and the end result. While I plan to open source some of this at some point, until I get more data, I'm unable to refine it enough to...
Why do 'sleep attacks' happen? Study points to an autoimmune trigger in narcolepsy
https://medicalxpress.com/news/2026-03-autoimmune-trigger-narcolepsy.html
Narcolepsy type 1 (NT1) is presumed to be an autoimmune disorder caused by hypothalamic loss of hypocretin (Hcrt; orexin). In postmortem NT1 brains, we observed an 11‐fold increase of CD4 + T‐cells in the Hcrt region compared with control hypothalami, without a corresponding rise in CD8 +...
Bezisterim-associated anti-inflammatory epigenetic modulation of age acceleration and Alzheimer’s disease genes
Abstract
Abstract Treatments with the ability to slow or reduce biological age have therapeutic potential in diseases of aging, including late-onset Alzheimer’s disease (AD). We...
An exploratory analysis of bezisterim treatment associated with decreased biological age acceleration, and improved clinical measure and biomarker changes in mild-to-moderate probable Alzheimer's disease
Abstract
Introduction Aging is the primary risk factor for sporadic Alzheimer's disease...
“Hi! We are slated for first-in-human mitochondrial transplantation this year. AND my announcement about the MMT therapy was 100% home-based. I’m excited to provide all sorts of options to all patients. My role is to build functional, actionable toolkits, not to sell magic bullets”
Putrino...
Good to know we can get our microglia replaced! I can breathe a sigh of relief.
The evolution of microglia replacement: A new paradigm for CNS disease therapy
https://www.sciencedirect.com/science/article/pii/S1934590925004072
Is someone able to summarize the discussion here in simpler English at some point for those of us with lower IQ’s? Are the study’s findings debunkable?
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