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  1. J

    Linking Genome-Wide Association Studies to Pharmacological Treatments for Psychiatric Disorders Arnatkeviciute 2025

    https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2827732 Key Points Question Do genes targeted by current treatments for psychiatric disorders match genetic variation identified through genome-wide association studies (GWAS), and what bioinformatic data modalities can inform these...
  2. J

    Medications that lower IGG

    Here is what JE said Until JE drops the next chapter of the ME/CFS chronicles, that’s about as much as we know.
  3. J

    Medications that lower IGG

    Hearing from people who knew of people in the Efgart trial that trial was poorly done and that many patients reported getting a lot better, including severe bed bound patients.
  4. J

    Medications that lower IGG

    Efgart failed for POTS. https://www.s4me.info/threads/efgartigimod-vyvgart-what-could-the-trial-data-possibly-tell-us.37316/ Did they look at fatigue/brain fog/sleep?
  5. J

    Medications that lower IGG

    Correct about Efgartigimod https://pmc.ncbi.nlm.nih.gov/articles/PMC6159959/ Neonatal Fc receptor antagonist efgartigimod safely and sustainably reduces IgGs in humans BACKGROUND. Intravenous Ig (IVIg), plasma exchange, and immunoadsorption are frequently used in the management of severe...
  6. J

    Medications that lower IGG

    Cleaned it up a bit
  7. J

    Medications that lower IGG

    With respect to this thread https://www.s4me.info/threads/autoantibody-targeting-therapies-in-post-covid-syndrome-and-myalgic-encephalomyelitis-chronic-fatigue-syndrome-2025-wohlrab-et-al.43586/ These are medications that lower IGG from 2 AI programs. I know some people don’t like it when I use...
  8. J

    Autoantibody targeting therapies in post COVID syndrome and myalgic encephalomyelitis/chronic fatigue syndrome, 2025, Wohlrab et al

    Here is your similar comment regarding IGG for the cyclo study Happy that you are coming over to the dark side now!
  9. J

    Autoantibody targeting therapies in post COVID syndrome and myalgic encephalomyelitis/chronic fatigue syndrome, 2025, Wohlrab et al

    Earlier I asked you about this and you said it wasn’t important. IGG measures total antibodies, correct? From both the Fluge cyclo and daratumumab studies there is no response in patients who didn’t lower their IGG levels.
  10. J

    SF-36 - a discussion

    FUNCAP does include questions related to cognitive function, but I don’t see any general questions about energy level or pep.
  11. J

    SF-36 - a discussion

    I don’t like SF 36 10 physical function questions but for completely different reasons. I score in normal healthy human ranges (and won’t vary over time for me) so these 10 questions wouldn’t tell you anything at all about me. I do like a couple of the SF 36 questions related to energy and pep—...
  12. J

    October 2025 IACFS/ME Conference

    Is there a suggestion that they are going to entertain pseudoscience? I looked at some previous agendas and it looked like there was some (e.g. KDM). But there were also a lot of student presentations, which I think is good/fine. Since this is in Nancy Klim*s place, I do have some concern...
  13. J

    Aripiprazole - Abilify

    Interesting. I’m guessing this is different—Dara kills cells expressing cd38, whereas apigenin inhibits the synthesis of CD38
  14. J

    ME/CFS and Long Covid - Digging Deeper 7-8 May 2025 | Stavanger | Norway

    This is posted under the Scandinavia thread but am posting as a stand alone as the registration deadline is approaching. https://www.mekonferanse.no/en/ We know people who are attending, correct? @Kalliope @Marky Are they attending both the May 7 day session and the May 8 night session? I am...
  15. J

    Babesia, babesiosis (tick-borne disease)

    Author is familiar with MECFS—see the commentary at the end of this article. https://www.yalemedicine.org/news/long-covid-mecfs-and-the-importance-of-studying-infection-associated-illnesses
  16. J

    Babesia, babesiosis (tick-borne disease)

    She Was Tired and Unsteady on Her Feet. Was It Just Age? Sounds like Babesia triggered MECFS. https://www.nytimes.com/2025/04/04/well/babesiosis-tick-borne-fatigue-flu-symptoms.html?unlocked_article_code=1.904.adws.NoXViK5GpztK&smid=url-share
  17. J

    CoRE: Long Covid, Lyme and related conditions clinic at Mt Sinai hospital

    Honestly, not much science behind this group/center.
  18. J

    Ozempic, tirzepatide and other GLP-1RAs - impact on ME/CFS

    Tirzepatide didn’t do anything for my MECFS symptoms.
  19. J

    Shingles vaccines, chickenpox, Shingrix

    Really? I thought it was the current one? Any evidence for the current one?
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