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https://en.wikipedia.org/wiki/Amitriptyline Ami is also a good sigma agonist but it is a really dirty drug.

Also Opipramol is another sigma agonist that a couple of patients (maybe one) has reported positive results on. Both Opipramol and fluv have about the same binding affinity for sigma one. Fluv doesn’t touch the dopamine receptors—opi does. Fluv has affinity for SERT—opi does not. I don’t...

https://www.medscape.com/viewarticle/special-antidepressant-treats-long-covid-2026a10009on?src=&form=fpf

“ Great piece from @thesicktimes about our participation in some #LongCOVID and infection-associated chronic condition and illness education in Santa Barbara. Great coverage of some of the challenges of CME-accredited education as well as the need for thesicktimes.org/2026/03/30/cal… 1/“...

This article seems to be making the rounds now even though it was published in 2024–surprised that it hadn’t been posted on here before.

“In 2017, Alina Sternberg, a psychiatrist, was hit with crushing fatigue and brain fog.Neurologists told her the symptoms were caused by depression."No, I can enjoy my life, and I know what depression is... I’m a psychiatrist!”It took 6 years to discover the culprit...” Thread

https://www.science.org/content/article/inflamed-brain-can-trigger-psychosis-search-patients-might-cured

Anyone can summarize? Thanks https://www.hemtrevligt.se/halsa/slapp-rullstol-efter-20-ar/1621032

Regarding that X comment, I don’t get the vibe that Putrino is a financial grifter. I also think he sincerely cares about ME/CFS patients. I just feel that he is in way over his head with respect to his own research capabilities, and I don’t think he understands this fact, and the damage it...

Here’s Hannah Davis, an expert in “bias in data sets” hyping the study https://en.wikipedia.org/wiki/Hannah_E._Davis “New paper shows an MMT (Microtesla Magnetic Therapy) device improves memory, verbal learning, processing speed, and more in #LongCovid patients with objective cognitive...

Is this similar to TMS device offered by some psychiatrists? “No. Very different. It is a continuous magnetic field rather than pulsed like TMS and it is about 1/100000th the strength of the magnet used in TMS. TMS is about stimulating neurons, MMT triggers reductions in neuroinflammation...

This is really shameful stuff. Also bugs me that a lot of comments on his X thread are really positive. Maybe @dave30th or @betsyladyzhets could cover this.

It’s the old green jelly beans cause acne study. https://xkcd.com/882/

This company https://sbpdiscovery.org/press/new-magnetic-therapy-could-transform-treatment-of-neuroinflammation-a-hidden-driver-of-brain-disease/

interesting p values…..

Putrino X Thread “Excited to get this out in preprint: triple-blind, placebo-controlled microtesla magnetic therapy (MMT) is safe, feasible and effective in reducing cognitive impairment in people with #LongCOVID. I get excited about interventions for cognitive symptoms…”

Abstract Background: Cognitive impairment has significant implications for function and quality of life and is common in individuals with post-acute sequelae of SARS CoV-2, also known as long COVID (LC). Emerging evidence suggests that sustained neuroinflammation, cerebrovascular dysfunction...

X thread on trap hypothesis

Abstract Background: Neurological Long COVID (n-LC) includes persistent cognitive and autonomic symptoms after SARS-CoV-2 infection. Prior studies of post-COVID conditions have described diverse humoral autoreactivity, but findings are heterogeneous, and it remains unclear whether n-LC is...

The Russian Dara will be IV not subQ. Any biosimilars that will be subQ?