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  1. J

    Teclistamab plus Daratumumab in Relapsed or Refractory Multiple Myeloma 2025 Costa et al.

  2. J

    Teclistamab plus Daratumumab in Relapsed or Refractory Multiple Myeloma 2025 Costa et al.

  3. J

    Teclistamab plus Daratumumab in Relapsed or Refractory Multiple Myeloma 2025 Costa et al.

    Abstract BACKGROUND In a phase 1–2 trial, teclistamab, a bispecific antibody targeting CD3 on T-cell surfaces and B-cell maturation antigen on myeloma cells, showed durable responses in heavily pretreated patients with relapsed or refractory multiple myeloma. Daratumumab, a monoclonal antibody...
  4. J

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    I guess we don’t know how much of “stuff” that comprises the IgG is bad stuff?
  5. J

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    @Jonathan Edwards Do you have any idea why IGG levels didn’t decrease after the three additional Daratumumab shots (please see post 406 above). I think this paper is saying that IGG doesn’t decrease after a certain point. https://pmc.ncbi.nlm.nih.gov/articles/PMC7271608/ If that is the case...
  6. J

    NYC-based ME/CFS doctors recs? (excluding Susan Levine)

    I’m not sure you want integrative care—that usually veers into pseudoscience...
  7. J

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    Yeah that sounds sketchy.
  8. J

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    For the seven shot cohort, IGG didn’t decrease with the 3 additional shots (the yellow arrows). Any ideas about this? Maybe Daratumumab can’t deplete any more cells without NK cells?
  9. J

    Oliver Sacks Put Himself Into His Case Studies. What Was the Cost?

    https://www.ucl.ac.uk/news/2024/oct/comment-mysterious-disease-inspired-awakenings-finally-starting-give-some-clues
  10. J

    Oliver Sacks Put Himself Into His Case Studies. What Was the Cost?

    I think the article could have been shortened by half or two thirds. Wish there had been more discussion about Encephalitis lethargica, which may be a disease closely related to ME/CFS. Also does anyone really need 50 years of psychoanalysis? Maybe the psychiatrist could have pulled the plug...
  11. J

    Oliver Sacks Put Himself Into His Case Studies. What Was the Cost?

    Um I read the New Yorker article…not sure you need to. Tldr Sacks “embellished” some of his case studies.
  12. J

    Ozempic, tirzepatide and other GLP-1RAs - impact on ME/CFS

  13. J

    Hypothesis Hypothesis: A Mechanical Basis: Brainstem Dysfunction as a Potential Etiology of ME/CFS and Long COVID, 2025, Jeff Wood, Kaufman et al.

  14. J

    A Study to Assess Anktiva in Patients With Long Covid-19. (INTERRUPT_LC)

    It’s on clinical trials. https://clinicaltrials.gov/study/NCT07123727 600ug of NAI administered subcutaneously
  15. J

    Emerging and underrecognized viral triggers of autoimmune inflammatory rheumatic disease flares, 2025, Melano et al

    Autoimmune rheumatic diseases (AIRDs), such as rheumatoid arthritis and systemic lupus erythematosus, substantially affect quality of life, with viral infections increasingly recognized as potential but underappreciated triggers of worsening preexisting AIRD symptoms. Despite growing evidence...
  16. J

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    Are we sure that Fluge specifically called out GPCR antibodies? @Jonathan Edwards has been skeptical of the German antibody claims. IIRC, his argument was that if these antibodies were a factor they would need to be much much higher than normal levels, and they weren’t.
  17. J

    I suspected a hidden killer lurked inside my body. Here’s what I found.—Preventative MRI’s

    Ugh…sorry for that.
  18. J

    I suspected a hidden killer lurked inside my body. Here’s what I found.—Preventative MRI’s

    Try it now—should have been a gift link. It’s about using “preventative” MRIs to catch early stage diseases/cancers. But insurance won’t pay for it. It’s a bit hard to summarize because there is a tongue in cheek element to the writing—which makes it a mostly fun read.
  19. J

    I suspected a hidden killer lurked inside my body. Here’s what I found.—Preventative MRI’s

    https://wapo.st/3MnLxPi Seems like others countries offer these MRIs as part of regular check ups.
  20. J

    Rob Wust looking for LC biopsy volunteers (Netherlands)

    What’s the payment? A giant wheel of Gouda cheese would get me there.
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